Li Wen-Jing, Wang Yong, Gong Yu, Tu Chao, Feng Tong-Bao, Qi Chun-Jian
Medical Research Center, the Affiliated Hospital of Nanjing Medical University, Changzhou No.2 People's Hospital, Changzhou, China E-mail :
Asian Pac J Cancer Prev. 2015;16(17):7905-9. doi: 10.7314/apjcp.2015.16.17.7905.
Several studies reported there was a polymorphism (rs531564 C > G) in miR-124 gene. To investigate the MiR-124 rs531564 polymorphism and cancer risk. We conducted a literature search of the Medline, Embase and Wangfang Medicine databases to identify all relevant studies for this meta-analysis. We determined that the miR-124 rs531564 polymorphism was significantly associated with decreased risks of cancers in the allelic model (G vs C, OR=0.71, 95% CI=0.53-0.94, P=0.02), homozygote model (GG vs CC, OR=0.42, 95% CI=0.26-0.66, P=0.0002), dominant model (GG/GC vs CC, OR=0.71, 95% CI=0.51-0.98, P=0.04) and recessive model (GG vs GC/CC, OR=0.43, 95% CI=0.27-0.69, P=0.0004). In an analysis stratified by cervical cancer group, significant associations were observed in the allelic model (G vs C, OR=0.46, 95% CI=0.32-0.66, P<0.0001), and dominant model (GG/GC vs CC, OR=0.45, 95% CI=0.3-0.66, P<0.0001). Subgroup analysis also revealed a decreased risk for esophageal squamous cell carcinoma in the homozygote model (GG vs CC, OR=0.45, 95% CI=0.27-0.75, P=0.002) and recessive model (GG vs GC/CC, OR=0.46, 95% CI=0.28-0.75, P=0.002). This meta-analysis suggests that the miR-124 rs531564 C > G polymorphism is an important risk factor for cancers among the Chinese population.
多项研究报告称，miR - 124基因存在一种多态性（rs531564 C>G）。为了探究MiR - 124 rs531564多态性与癌症风险的关系。我们对Medline、Embase和万方医学数据库进行了文献检索，以确定所有与该荟萃分析相关的研究。我们发现，在等位基因模型（G对C，OR = 0.71，95%CI = 0.53 - 0.94，P = 0.02）、纯合子模型（GG对CC，OR = 0.42，95%CI = 0.26 - 0.66，P = 0.0002）、显性模型（GG/GC对CC，OR = 0.71，95%CI = 0.51 - 0.98，P = 0.04）和隐性模型（GG对GC/CC，OR = 0.43，95%CI = 0.27 - 0.69，P = 0.0004）中，miR - 124 rs531564多态性与癌症风险降低显著相关。在按宫颈癌组分层的分析中，在等位基因模型（G对C，OR = 0.46，95%CI = 0.32 - 0.66，P<0.0001）和显性模型（GG/GC对CC，OR = 0.45，95%CI = 0.3 - 0.66，P<0.0001）中观察到显著关联。亚组分析还显示，在纯合子模型（GG对CC，OR = 0.45，95%CI = 0.27 - 0.75，P = 0.002）和隐性模型（GG对GC/CC，OR = 0.46，95%CI = 0.28 - 0.75，P = 0.002）中，食管鳞状细胞癌风险降低。这项荟萃分析表明，miR - 124 rs531564 C>G多态性是中国人群中癌症的一个重要风险因素。
