Barros Eliana Nogueira Castro de, Cintra Otavio, Rossetto Erika, Freitas Laís, Colindres Romulo
GSK Vaccines, Rio de Janeiro, RJ, Brazil.
GSK Vaccines, Rio de Janeiro, RJ, Brazil.
Braz J Infect Dis. 2016 Jan-Feb;20(1):81-90. doi: 10.1016/j.bjid.2015.09.009. Epub 2015 Nov 25.
Data on the burden of disease and circulation patterns of influenza B lineages for Brazil are limited. This review aims to describe the pattern of influenza B occurrence in Brazil to have a better understanding of its epidemiology and its relevance when considering seasonal influenza vaccine composition. A review of the data including analysis of international and local surveillance data as well as information from online search of databases using Medical Subject Headings terms in conjunction with screening of abstracts from scientific events was performed. Based on international epidemiologic surveillance data, moderate levels of influenza B disease (19%; 2006-2014) were observed. Of these nine years, it was possible to compare data from three years (2007, 2008 and 2013) which have information on the circulating influenza B lineage. Co-circulation of influenza B lineages was observed in all these three influenza seasons, of which, during one season, a high degree of mismatch between the vaccine lineage and the predominant circulating lineage (91.4% [2013]) was observed. Local surveillance data reveal a distinct and dynamic distribution of respiratory viruses over the years. Data from published literature and abstracts show that influenza B is a significant cause of disease with an unpredictable circulation pattern and showing trends indicating reemergence of the B/Victoria lineage. The abstracts report notable levels of co-circulation of both influenza B lineages (2000-2013). Mismatch between the Southern hemisphere vaccine and the most prevalent circulating viruses in Brazil were observed in five influenza seasons. The evidence on co-circulation of two influenza B lineages and mismatched seasons in Brazil indicates the benefit of quadrivalent influenza vaccines in conferring broader seasonal influenza protection. Additionally, improving influenza surveillance platforms in Brazil is important for monitoring disease trends and the impact of introducing seasonal influenza vaccination.
关于巴西乙型流感病毒谱系的疾病负担和传播模式的数据有限。本综述旨在描述巴西乙型流感的发生模式，以便在考虑季节性流感疫苗组成时更好地了解其流行病学及其相关性。我们对数据进行了综述，包括分析国际和本地监测数据，以及使用医学主题词对数据库进行在线搜索，并结合对科学活动摘要的筛选。根据国际流行病学监测数据，观察到乙型流感疾病处于中等水平（19%；2006 - 2014年）。在这九年中，可以比较三年（2007年、2008年和2013年）的数据，这些年份有关于流行的乙型流感病毒谱系的信息。在所有这三个流感季节中均观察到乙型流感病毒谱系的共同流行，其中在一个季节中，观察到疫苗谱系与主要流行谱系之间存在高度不匹配（91.4% [2013年]）。本地监测数据显示，多年来呼吸道病毒的分布具有独特性和动态性。来自已发表文献和摘要的数据表明，乙型流感是一种重要的致病原因，其传播模式不可预测，并且显示出B/维多利亚谱系重新出现的趋势。摘要报告了两个乙型流感病毒谱系的显著共同流行水平（2000 - 2013年）。在五个流感季节中观察到南半球疫苗与巴西最普遍流行的病毒之间存在不匹配。巴西两个乙型流感病毒谱系共同流行和季节不匹配的证据表明，四价流感疫苗在提供更广泛的季节性流感保护方面具有益处。此外，改善巴西的流感监测平台对于监测疾病趋势和引入季节性流感疫苗接种的影响非常重要。
