Cardona-Ospina Jaime A, Villamil-Gómez Wilmer E, Jimenez-Canizales Carlos E, Castañeda-Hernández Diana M, Rodríguez-Morales Alfonso J
Research Group Public Health and Infection, Faculty of Health Sciences, Universidad Tecnológica de Pereira, 660003, Pereira, Risaralda, Colombia.
Infectious Diseases and Infection Control Research Group, Hospital Universitario de Sincelejo, Sincelejo, Sucre, Colombia Programa del Doctorado de Medicina Tropical, Universidad de Cartagena, Cartagena, Universidad del Atlántico, Barranquilla, Colombia Committee on Zoonoses and Haemorrhagic Fevers, Asociación Colombiana de Infectología (ACIN), Bogota, DC, Colombia.
Trans R Soc Trop Med Hyg. 2015 Dec;109(12):793-802. doi: 10.1093/trstmh/trv094.
Chikungunya (CHIK) virus disease is expected to be a considerable cause of disability and economic burden in Latin America given its chronic sequelae, particularly its chronic inflammatory rheumatism. There have been no previous studies assessing CHIK costs and disability in Latin America.
We calculated incidence rates for CHIK during the 2014 outbreak in Colombia using epidemiological data provided by the Colombian National Institute of Health, using demographic data from the National Administrative Department of Statistics. The burden of disease was estimated through disability adjusted life years (DALYs) lost and the costs were estimated based on the national recommendations for CHIK acute and chronic phase attention.
There were a total of 106 592 cases, with incidence rates ranging from 0 to 1837.3 cases/100 000 population in different departments. An estimate was made of total DALYs lost of 40.44 to 45.14 lost/100 000 population. The 2014 outbreak estimated costs were at least US$73.6 million.
Our estimates raise concerns about the effects of continued CHIK spread in Colombia and other Latin-American countries. The lack of transmission control for this disease and potential for spread means that there will be significant acute and chronic disability and related costs in the short and long term for Latin American health care systems.
鉴于基孔肯雅（CHIK）病毒病的慢性后遗症，尤其是慢性炎症性风湿病，预计该病将成为拉丁美洲残疾和经济负担的一个重要原因。此前尚无评估拉丁美洲基孔肯雅热的成本和残疾情况的研究。
我们利用哥伦比亚国家卫生研究所提供的流行病学数据，并结合国家统计局的人口数据，计算了2014年哥伦比亚疫情期间基孔肯雅热的发病率。通过失能调整生命年（DALYs）估算疾病负担，并根据国家对基孔肯雅热急性期和慢性期治疗的建议估算成本。
总共报告了106592例病例，不同部门的发病率从0至1837.3例/10万人口不等。估计每10万人口的总失能调整生命年损失为40.44至45.14。2014年疫情的估计成本至少为7360万美元。
我们的估计引发了对基孔肯雅热在哥伦比亚和其他拉丁美洲国家持续传播影响的担忧。对该疾病缺乏传播控制以及传播的可能性意味着，拉丁美洲医疗系统在短期和长期内将面临重大的急性和慢性残疾及相关成本。
