de Roo Adrianne Marije, Vondeling Gerard Timmy, Boer Martijn, Murray Kristy, Postma Maarten Jacobus
Valneva Austria GmbH, Vienna, Austria
Department of Health Sciences, University of Groningen, Groningen, Netherlands.
BMJ Glob Health. 2024 Dec 3;9(12):e016648. doi: 10.1136/bmjgh-2024-016648.
Chikungunya is a mosquito-borne arboviral disease posing an emerging global public health threat. Understanding the global burden of chikungunya is critical for designing effective prevention and control strategies. However, current estimates of the economic and health impact of chikungunya remain limited and are potentially underestimated. This study aims to provide a comprehensive overview of the chikungunya burden worldwide.
We analysed the global burden of chikungunya between 2011 and 2020 and calculated disability-adjusted life years (DALYs) and direct and indirect costs using a data-driven simulation model. The main outcomes were the number of cases, the total DALY burden, and the direct and indirect costs of acute and chronic chikungunya between 2011 and 2020.
Our study revealed a total of 18.7 million chikungunya cases in 110 countries between 2011 and 2020, causing 1.95 million DALYs. Most of this burden was found in the Latin American and Caribbean region. The total economic burden caused by chikungunya over these 10 years was estimated at $2.8 billion in direct costs and $47.1 billion in indirect costs worldwide. Long-term chronic illness was the source of most costs and DALYs.
Chikungunya has a higher disease burden than was previously estimated and costs related to the disease are substantial. Especially in combination with its unpredictable nature, chikungunya could significantly impact local health systems. Insights from this study could inform decision makers on the impact of chikungunya on population health and help them to appropriately allocate resources to protect vulnerable populations from this debilitating disease.
基孔肯雅热是一种由蚊子传播的虫媒病毒病，对全球公共卫生构成新出现的威胁。了解基孔肯雅热的全球负担对于制定有效的预防和控制策略至关重要。然而，目前对基孔肯雅热经济和健康影响的估计仍然有限，而且可能被低估。本研究旨在全面概述全球基孔肯雅热负担。
我们分析了2011年至2020年期间基孔肯雅热的全球负担，并使用数据驱动的模拟模型计算了伤残调整生命年（DALYs）以及直接和间接成本。主要结果是2011年至2020年期间急性和慢性基孔肯雅热的病例数、总DALY负担以及直接和间接成本。
我们的研究显示，2011年至2020年期间，110个国家共有1870万例基孔肯雅热病例，导致195万个伤残调整生命年。大部分负担集中在拉丁美洲和加勒比地区。这10年间基孔肯雅热在全球造成的总经济负担估计为直接成本28亿美元，间接成本471亿美元。长期慢性病是大部分成本和伤残调整生命年的来源。
基孔肯雅热的疾病负担高于先前估计，与该疾病相关的成本巨大。特别是考虑到其不可预测的性质，基孔肯雅热可能会对当地卫生系统产生重大影响。本研究的见解可为决策者提供有关基孔肯雅热对人群健康影响的信息，并帮助他们适当分配资源，以保护弱势群体免受这种使人衰弱的疾病的侵害。
