Chen Liangdong, Zhuo Deqiang, Chen Jiakuan, Yuan Hongyin
Department of Oncology, Zhongnan Hospital, Wuhan University Wuhan 430071, PR China.
Int J Clin Exp Med. 2015 Sep 15;8(9):14969-76. eCollection 2015.
X-ray repair cross-complementing group 1 (XRCC1) plays an important role in the base excision repair. Many studies have reported the association of XRCC1 Arg399Gln, Arg194Trp and Arg280His polymorphisms with lung cancer risk, but the results remained controversial. In this meta-analysis, we performed a meta-analysis of ten published case-control studies in Caucasian populations to investigate the associations between lung cancer risk and XRCC1 Arg399Gln (2187 cases and 3453 controls from ten studies), Arg194Trp (857 cases and 2108 controls from six studies) and Arg280His (894 cases and 1133 controls from five studies). The results in total population showed that XRCC1 codon 399 polymorphism (OR=0.93, 95% CI=0.82-1.04) and codon 194 (OR=0.94, 95% CI=0.73-1.21) was significantly associated with lung cancer risk. However, no association was found between lung cancer risk and codon 280 (OR=1.17, 95% CI=0.89-1.54). In conclusion, this meta-analysis has demonstrated that codon 399 and codon 194 might have contributed to individual susceptibility to lung cancer in Caucasian populations. To further evaluate effect of XRCC1 polymorphisms, large studies with thousands of subjects are required to get conclusive results.
X射线修复交叉互补基因1（XRCC1）在碱基切除修复中起重要作用。许多研究报道了XRCC1基因的Arg399Gln、Arg194Trp和Arg280His多态性与肺癌风险的关联，但结果仍存在争议。在这项荟萃分析中，我们对已发表的十项针对白种人群体的病例对照研究进行了荟萃分析，以调查肺癌风险与XRCC1基因的Arg399Gln（来自十项研究的2187例病例和3453例对照）、Arg194Trp（来自六项研究的857例病例和2108例对照）以及Arg280His（来自五项研究的894例病例和1133例对照）之间的关联。总体人群的结果显示，XRCC1基因第399密码子多态性（OR = 0.93，95%CI = 0.82 - 1.04）和第194密码子（OR = 0.94，95%CI = 0.73 - 1.21）与肺癌风险显著相关。然而，未发现肺癌风险与第280密码子之间存在关联（OR = 1.17，95%CI = 0.89 - 1.54）。总之，这项荟萃分析表明，第399密码子和第194密码子可能影响白种人群体中个体对肺癌的易感性。为进一步评估XRCC1基因多态性的影响，需要开展涉及数千名受试者的大规模研究以获得确凿结果。
