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本文引用的文献

1
ING5 suppresses proliferation, apoptosis, migration and invasion, and induces autophagy and differentiation of gastric cancer cells: a good marker for carcinogenesis and subsequent progression.ING5抑制胃癌细胞的增殖、凋亡、迁移和侵袭，并诱导自噬和分化：是癌变及后续进展的良好标志物。
Oncotarget. 2015 Aug 14;6(23):19552-79. doi: 10.18632/oncotarget.3735.
2
ING5 inhibits cancer aggressiveness via preventing EMT and is a potential prognostic biomarker for lung cancer.ING5通过阻止上皮-间质转化抑制癌症侵袭性，是肺癌潜在的预后生物标志物。
Oncotarget. 2015 Jun 30;6(18):16239-52. doi: 10.18632/oncotarget.3842.
3
Reduced ING1 levels in breast cancer promotes metastasis.乳腺癌中ING1水平降低会促进转移。
Oncotarget. 2014 Jun 30;5(12):4244-56. doi: 10.18632/oncotarget.1988.
4
TGF-β signaling and epithelial-mesenchymal transition in cancer progression.TGF-β 信号通路与癌症进展中的上皮间质转化。
Curr Opin Oncol. 2013 Jan;25(1):76-84. doi: 10.1097/CCO.0b013e32835b6371.
5
Sequence analysis of mutations and translocations across breast cancer subtypes.乳腺癌亚型突变和易位的序列分析。
Nature. 2012 Jun 20;486(7403):405-9. doi: 10.1038/nature11154.
6
The nuclear to cytoplasmic shift of ING5 protein during colorectal carcinogenesis with their distinct links to pathologic behaviors of carcinomas.ING5 蛋白在结直肠癌变过程中的核质转移及其与癌病理行为的明确联系。
Hum Pathol. 2011 Mar;42(3):424-33. doi: 10.1016/j.humpath.2009.12.018. Epub 2010 Dec 28.
7
The altered expression of ING5 protein is involved in gastric carcinogenesis and subsequent progression.ING5 蛋白表达的改变与胃癌的发生和随后的进展有关。
Hum Pathol. 2011 Jan;42(1):25-35. doi: 10.1016/j.humpath.2010.05.024. Epub 2010 Nov 9.
8
Tumor-suppressive effect of adenovirus-mediated inhibitor of growth 4 gene transfer in breast carcinoma cells in vitro and in vivo.腺病毒介导的生长抑制因子 4 基因转移对乳腺癌细胞的体内外抑瘤作用。
Cancer Biother Radiopharm. 2010 Aug;25(4):427-37. doi: 10.1089/cbr.2010.0778.
9
Treatment of breast cancer.乳腺癌治疗。
Am Fam Physician. 2010 Jun 1;81(11):1339-46.
10
Decreased nuclear expression and increased cytoplasmic expression of ING5 may be linked to tumorigenesis and progression in human head and neck squamous cell carcinoma.ING5 的核表达减少和胞质表达增加可能与人类头颈部鳞状细胞癌的发生和进展有关。
J Cancer Res Clin Oncol. 2010 Oct;136(10):1573-83. doi: 10.1007/s00432-010-0815-x. Epub 2010 Feb 25.

ING5通过抑制PI3K/Akt信号通路来抑制乳腺癌中的上皮-间质转化。

ING5 inhibits epithelial-mesenchymal transition in breast cancer by suppressing PI3K/Akt pathway.

作者信息

Zhao Qing-Ye, Ju Fang, Wang Zhi-Hai, Ma Xue-Zhen, Zhao Hui

机构信息

Department of Oncology, The Second Affiliated Hospital of Medical College Qing Dao University Qingdao 266042, China.

Department of Mammary Gland, The Second Affiliated Hospital of Medical College Qing Dao University Qingdao 266042, China.

出版信息

Int J Clin Exp Med. 2015 Sep 15;8(9):15498-505. eCollection 2015.

PMID:26629040
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4658929/
Abstract

Epithelial-mesenchymal transition (EMT) is a crucial step in tumor progression and has an important role during cancer invasion and metastasis. The proteins of the inhibitor of growth (ING) candidate tumor suppressor family are involved in multiple cellular functions such as cell cycle regulation and apoptosis. ING5 is a member of the family. However, the role of ING5 in breast cancer is still unclear. Thus, the aim of this study is to explore the role of ING5 in breast cancer. In the present study, we showed that ING5 is involved in the pathogenesis of breast cancer. ING5 is down-regulated in breast cancer tissues and cell lines. Overexpression of ING5 significantly inhibited breast cancer cell migration, invasion, and EMT phenotype, moreover, overexpression of ING5 significantly the phosphorylation of PI3K and Aktin in breast cancer cells. In conclusion, our findings show that ING5 can efficiently inhibit the EMT progression in breast cancer cells by suppressing PI3K/Akt signaling pathway. Therefore, ING5 may be a good molecular target for the prevention and treatment of breast cancer.

摘要

上皮-间质转化（EMT）是肿瘤进展中的关键步骤，在癌症侵袭和转移过程中发挥重要作用。生长抑制因子（ING）候选肿瘤抑制家族的蛋白质参与多种细胞功能，如细胞周期调控和细胞凋亡。ING5是该家族的成员之一。然而，ING5在乳腺癌中的作用仍不清楚。因此，本研究的目的是探讨ING5在乳腺癌中的作用。在本研究中，我们发现ING5参与乳腺癌的发病机制。ING5在乳腺癌组织和细胞系中表达下调。ING5的过表达显著抑制乳腺癌细胞的迁移、侵袭和EMT表型，此外，ING5的过表达显著抑制乳腺癌细胞中PI3K和Akt的磷酸化。总之，我们的研究结果表明，ING5可以通过抑制PI3K/Akt信号通路有效抑制乳腺癌细胞的EMT进程。因此，ING5可能是预防和治疗乳腺癌的良好分子靶点。