ING5通过抑制PI3K/Akt信号通路来抑制乳腺癌中的上皮-间质转化。
ING5 inhibits epithelial-mesenchymal transition in breast cancer by suppressing PI3K/Akt pathway.
作者信息
Zhao Qing-Ye, Ju Fang, Wang Zhi-Hai, Ma Xue-Zhen, Zhao Hui
机构信息
Department of Oncology, The Second Affiliated Hospital of Medical College Qing Dao University Qingdao 266042, China.
Department of Mammary Gland, The Second Affiliated Hospital of Medical College Qing Dao University Qingdao 266042, China.
出版信息
Int J Clin Exp Med. 2015 Sep 15;8(9):15498-505. eCollection 2015.
Epithelial-mesenchymal transition (EMT) is a crucial step in tumor progression and has an important role during cancer invasion and metastasis. The proteins of the inhibitor of growth (ING) candidate tumor suppressor family are involved in multiple cellular functions such as cell cycle regulation and apoptosis. ING5 is a member of the family. However, the role of ING5 in breast cancer is still unclear. Thus, the aim of this study is to explore the role of ING5 in breast cancer. In the present study, we showed that ING5 is involved in the pathogenesis of breast cancer. ING5 is down-regulated in breast cancer tissues and cell lines. Overexpression of ING5 significantly inhibited breast cancer cell migration, invasion, and EMT phenotype, moreover, overexpression of ING5 significantly the phosphorylation of PI3K and Aktin in breast cancer cells. In conclusion, our findings show that ING5 can efficiently inhibit the EMT progression in breast cancer cells by suppressing PI3K/Akt signaling pathway. Therefore, ING5 may be a good molecular target for the prevention and treatment of breast cancer.
上皮-间质转化（EMT）是肿瘤进展中的关键步骤，在癌症侵袭和转移过程中发挥重要作用。生长抑制因子（ING）候选肿瘤抑制家族的蛋白质参与多种细胞功能，如细胞周期调控和细胞凋亡。ING5是该家族的成员之一。然而，ING5在乳腺癌中的作用仍不清楚。因此，本研究的目的是探讨ING5在乳腺癌中的作用。在本研究中，我们发现ING5参与乳腺癌的发病机制。ING5在乳腺癌组织和细胞系中表达下调。ING5的过表达显著抑制乳腺癌细胞的迁移、侵袭和EMT表型，此外，ING5的过表达显著抑制乳腺癌细胞中PI3K和Akt的磷酸化。总之，我们的研究结果表明，ING5可以通过抑制PI3K/Akt信号通路有效抑制乳腺癌细胞的EMT进程。因此，ING5可能是预防和治疗乳腺癌的良好分子靶点。
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