BLCA1表达与膀胱癌的血管生成相关，并与常见的促血管生成因子相关。
BLCA1 expression is associated with angiogenesis of bladder cancer and is correlated with common pro-angiogenic factors.
作者信息
Feng Chenchen, Wang Lujia, Ding Guanxiong, Jiang Haowen, Ding Qiang, Wu Zhong
机构信息
Department of Urology, Huashan Hospital, Fudan University Shanghai 200040, PR China.
出版信息
Int J Clin Exp Med. 2015 Sep 15;8(9):16259-65. eCollection 2015.
AIM
To study the association between expression of BLCA1 and clinicopathological parameters of bladder cancer.
METHOD
Seventy-seven bladder cancer tissue samples were collected and primary antibody of BLCA1 was generated via animal inoculation. Immunohistochemical staining of BLCA1 and several pro-angiogenic factors were performed and evaluated semi-quantitatively. Statistical analyses were used to reveal the associations therein.
RESULTS
Expression of BLCA-1 was not associated with tumor characteristics such as occurrence, size, or onset pattern, but was associated with progression of tumor grade, stage, and with muscle invasion. BLCA1 expression was correlated with expression of VEGF, MMP9, IL1α, IL8, and microvessel density (MVD), but not with TNFα expression.
CONCLUSION
BLCA1 is associated with progression of bladder cancer and paly a role in angiogenesis in bladder cancer.
目的
研究BLCA1表达与膀胱癌临床病理参数之间的关联。
方法
收集77例膀胱癌组织样本，通过动物接种制备BLCA1的一抗。对BLCA1和几种促血管生成因子进行免疫组织化学染色并进行半定量评估。采用统计学分析揭示其中的关联。
结果
BLCA-1的表达与肿瘤的发生、大小或发病模式等肿瘤特征无关，但与肿瘤分级、分期的进展以及肌肉浸润有关。BLCA1表达与VEGF、MMP9、IL1α、IL8的表达以及微血管密度（MVD）相关，但与TNFα表达无关。
结论
BLCA1与膀胱癌的进展相关，并在膀胱癌血管生成中发挥作用。
Zotero 插件