Khiroya Heena, Turner Alice M
School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT UK ; Centre for Translational Inflammation Research, Queen Elizabeth Hospital, Mindelsohn Way, Edgbaston, Birmingham, B15 2GW UK.
School of Clinical and Experimental Medicine, University of Birmingham, Birmingham, B15 2TT UK ; Heartlands Hospital, Bordesley Green East, Birmingham, B9 5SS UK.
Multidiscip Respir Med. 2015 Dec 1;10:34. doi: 10.1186/s40248-015-0031-2. eCollection 2015.
Respiratory disease accounts for a large proportion of emergency admissions to hospital and diseaseassociated mortality. Genetic association studies demonstrate a link between iron metabolism and pulmonary disease phenotypes. IREB2 is a gene that produces iron regulatory protein 2 (IRP2), which has a key role in iron homeostasis. This review addresses pathways involved in iron metabolism, particularly focusing on the role of IREB2. In addition to this, environmental factors also influence phenotypic variation in respiratory disease, for example inhaled iron from cigarette smoke is deposited in the lung and causes tissue damage by altering iron homeostasis. The effects of cigarette smoke are detailed in this article, particularly in relation to lung conditions that favour the upper lobes, such as emphysema and lung cancer. Clinical applications of iron homeostasis are also discussed in this review, especially looking at the pathophysiology of chronic obstructive pulmonary disease, lung cancer, pulmonary infections and acute respiratory distress syndrome. Promising new treatments involving iron are also covered.
呼吸系统疾病在医院急诊入院病例和疾病相关死亡率中占很大比例。基因关联研究表明铁代谢与肺部疾病表型之间存在联系。IREB2是一种产生铁调节蛋白2（IRP2）的基因，它在铁稳态中起关键作用。本综述探讨了铁代谢相关途径，特别关注IREB2的作用。除此之外，环境因素也会影响呼吸系统疾病的表型变异，例如香烟烟雾中的吸入性铁沉积在肺部，并通过改变铁稳态导致组织损伤。本文详细阐述了香烟烟雾的影响，特别是与好发于上叶的肺部疾病，如肺气肿和肺癌的关系。本综述还讨论了铁稳态的临床应用，尤其着眼于慢性阻塞性肺疾病、肺癌、肺部感染和急性呼吸窘迫综合征的病理生理学。还涵盖了涉及铁的有前景的新疗法。
