Dobbie J W
Baxter Healthcare Corporation, Round Lake, Ill.
Blood Purif. 1989;7(2-3):74-85. doi: 10.1159/000169580.
Stimulated by the development of continuous ambulatory peritoneal dialysis (CAPD), it was only in the last decade that normal and dialysate-exposed peritoneum were examined by electron microscopy. Biopsies of parietal peritoneum from patients on CAPD show ultrastructural alterations in the mesothelium consisting of an increased development of the rough endoplasmic reticulum but a decrease in surface microvilli and micropinocytotic vesicles as compared to tissue from normal controls or uremic individuals. Alterations in amount and consistency of submesothelial ground substance, and number and disposition of collagen fibers combined with mesothelial changes together constitute the 'reactive' peritoneum of peritoneal dialysis.
受持续性非卧床腹膜透析（CAPD）发展的刺激，直到最近十年，才通过电子显微镜对正常腹膜和接触透析液的腹膜进行了检查。CAPD患者壁层腹膜活检显示，与正常对照组织或尿毒症患者组织相比，间皮的超微结构改变包括粗面内质网发育增加，但表面微绒毛和微饮小泡减少。间皮下基质的数量和稠度变化、胶原纤维的数量和排列，以及间皮变化共同构成了腹膜透析的“反应性”腹膜。
