Di Paolo N, Sacchi G, De Mia M, Gaggiotti E, Capotondo L, Rossi P, Bernini M, Pucci A M, Ibba L, Sabatelli P
Nephron. 1986;44(3):204-11. doi: 10.1159/000183987.
In the last 3 years we performed 52 peritoneal biopsies (PB) in 31 patients on continuous ambulatory peritoneal dialysis (CAPD). Samples of the parietal peritoneum were obtained either during insertion of the catheter or while it was being repositioned or removed. PB was performed in 13 patients before initiating CAPD and in 27 after 7-49 months of CAPD while 7 had PB during peritonitis, and, again, in 5 of these cases, PB was repeated after 1-4 months for light, electron transmission, and scanning electron microscopy. BP after CAPD showed that mesothelial cells were irregularly spaced, and at times we observed alterations in the cellular structure. Rarely were these cells degenerating, while rarefaction and in many cases complete absence of microvilli were observed. In some cases the submesothelial layers showed rarefaction of the connective tissue and sclerosis. During peritonitis, PB showed more alterations with marked degeneration and in some cases necrosis of the mesothelium and alterations of connective tissue. PB performed some months after peritonitis showed only a partial regression of these alterations and sclerotic patches, and no microvilli were noted in the mesothelium.
在过去3年中，我们对31例持续非卧床腹膜透析（CAPD）患者进行了52次腹膜活检（PB）。壁层腹膜样本在置管时、重新置管或拔管时获取。13例患者在开始CAPD之前进行了PB，27例在CAPD进行7至49个月后进行，7例在腹膜炎期间进行PB，其中5例在1至4个月后再次进行PB，用于光镜、电子透射和扫描电子显微镜检查。CAPD后的PB显示间皮细胞间距不规则，有时我们观察到细胞结构改变。这些细胞很少发生退变，同时观察到微绒毛稀疏，在许多情况下完全缺失。在某些病例中，间皮下层显示结缔组织稀疏和硬化。在腹膜炎期间，PB显示出更多改变，包括间皮明显退变，在某些情况下坏死以及结缔组织改变。腹膜炎数月后进行的PB显示这些改变和硬化斑仅部分消退，间皮中未观察到微绒毛。
