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从波哥大牛膝菊（Achyrocline bogotensis (Kunth) DC.，菊科）中获得的物质对轮状病毒和星状病毒感染的体外抗病毒活性。

In vitro antiviral activity against rotavirus and astrovirus infection exerted by substances obtained from Achyrocline bogotensis (Kunth) DC. (Compositae).

作者信息

Téllez M A, Téllez A N, Vélez F, Ulloa J C

机构信息

Laboratorio de Virología, Departamento de Microbiología, Facultad de Ciencias, Grupo de Enfermedades Infecciosas, Pontificia Universidad Javeriana, Cra. 7 # 43-82, Bogotá, Colombia.

Laboratorio de Fitoquímica, Departamento de Química, Facultad de Ciencias, Grupo de Investigación en Fitoquímica, Pontificia Universidad Javeriana, Bogotá, Colombia.

出版信息

BMC Complement Altern Med. 2015 Dec 3;15(1):428. doi: 10.1186/s12906-015-0949-0.

DOI:10.1186/s12906-015-0949-0
PMID:26630872
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4668688/
Abstract

BACKGROUND

Achyrocline bogotensis has been traditionally used to treat infections of skin, respiratory, tract urinary and other infections, but not to treat viral gastrointestinal disease. In this study, this Colombian native medicinal plant was investigated by its in vitro anti-rotavirus and anti-astrovirus activity.

METHODS

Several extracts and fractions phytochemically obtained from A. bogotensis were evaluated initially for their cell toxicity on MA104 and Caco2 cells and then for their anti-rotavirus (RRV) and anti-astrovirus (Yuc8) activity following three strategies: pre-treatment of cells (blocking effect), direct viral activity (virucidal effect) and post-treatment of infected cells (reduction of viral yield post-infection). In addition qualitative chemical studies were developed for the active compounds.

RESULTS

Non-toxic concentrations of a fraction obtained exhibited antiviral activity against both viruses characterized by a virucidal effect and by the reduction of the infectious particles produced post-infection. Steroids, sterols, terpenes, phenols, flavonoids and sesquiterpenlactones were identified qualitatively in the active fraction.

CONCLUSIONS

A. bogotensis contains substances with in vitro antiviral activity against rotavirus and astrovirus. This study confirms their anti-microbial properties and describes by the first time its antiviral activity in vitro.

摘要

背景

传统上，波哥大牛膝菊被用于治疗皮肤、呼吸道、泌尿道感染及其他感染，但未用于治疗病毒性胃肠道疾病。在本研究中，对这种哥伦比亚本土药用植物的体外抗轮状病毒和抗星状病毒活性进行了研究。

方法

首先评估了从波哥大牛膝菊中通过植物化学方法获得的几种提取物和馏分对MA104和Caco2细胞的细胞毒性，然后按照三种策略评估其抗轮状病毒（RRV）和抗星状病毒（Yuc8）活性：细胞预处理（阻断作用）、直接病毒活性（杀病毒作用）和感染细胞后处理（感染后病毒产量降低）。此外，还对活性化合物进行了定性化学研究。

结果

所获得的一个馏分的无毒浓度对两种病毒均表现出抗病毒活性，其特征为具有杀病毒作用以及降低感染后产生的感染性颗粒数量。在活性馏分中定性鉴定出了类固醇、甾醇、萜类、酚类、黄酮类和倍半萜内酯。

结论

波哥大牛膝菊含有具有体外抗轮状病毒和抗星状病毒活性的物质。本研究证实了其抗菌特性，并首次描述了其体外抗病毒活性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/f7c73b3607dd/12906_2015_949_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/6ad9624aa5b2/12906_2015_949_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/b0d1c937afba/12906_2015_949_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/57fa0b77c57a/12906_2015_949_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/f7c73b3607dd/12906_2015_949_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/6ad9624aa5b2/12906_2015_949_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/b0d1c937afba/12906_2015_949_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/57fa0b77c57a/12906_2015_949_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9b3b/4668688/f7c73b3607dd/12906_2015_949_Fig4_HTML.jpg

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