Gan J H, Sim C Y L, Santorelli L A
Department of Sport and Health Science, Oxford Brookes University, Oxford, UK; Rehabilitation Department, Parkway East Hospital, Singapore.
Rehabilitation Department, Parkway East Hospital, Singapore.
Crit Rev Oncol Hematol. 2016 Feb;98:275-89. doi: 10.1016/j.critrevonc.2015.11.005. Epub 2015 Nov 17.
A limited number of clinical studies have investigated the effectiveness of participation in exercise training programmes for patients with multiple myeloma (MM), exploring the different biomedical, physical, psychological and quality of life. The aim of this literature review is to evaluate current quantitative and qualitative evidence concerning the effectiveness of participation in exercise programmes for patients with MM in improving physiological and/or psychological status. A literature search encompassing studies published between January 1998 and July 2013 was conducted through ten electronic databases. This search was further expanded through citation chaining, manual grey literature searches, and peer review consultation. In total, seven interventional studies were identified and appraised using Critical Appraisal Skill Programme (CASP) or Centre for Evidence-Based Management of Amsterdam (CEBMa). Though the majority of the studies presented encouraging data, however, three studies that implemented individualized exercise interventions for patients at different stages of MM and myeloablative treatment showed mixed results. In conclusion, the effectiveness of participation in exercise programmes remains unclear for patients with MM, as the studies reviewed were flawed by relatively weak methodological approaches.
仅有少数临床研究调查了参加运动训练项目对多发性骨髓瘤（MM）患者的有效性，探讨了不同的生物医学、身体、心理和生活质量方面。这篇文献综述的目的是评估当前关于MM患者参加运动项目在改善生理和/或心理状态方面有效性的定量和定性证据。通过十个电子数据库对1998年1月至2013年7月发表的研究进行了文献检索。通过引用链、手动灰色文献检索和同行评审咨询进一步扩大了搜索范围。总共确定了七项干预性研究，并使用批判性评估技能计划（CASP）或阿姆斯特丹循证管理中心（CEBMa）进行了评估。尽管大多数研究呈现出令人鼓舞的数据，然而，三项针对MM不同阶段和清髓治疗患者实施个体化运动干预的研究结果喜忧参半。总之，MM患者参加运动项目的有效性仍不明确，因为所审查的研究存在方法相对薄弱的缺陷。
