Fujita Takayuki, Watanabe Hidetsuna, Murata Yusuke, Hemmi Seiichiro, Yabuki Minako, Fuke Yoshinobu, Satomura Atsushi, Soma Masayoshi
Department of Nephrology, Hypertension and Endocrinology, Nihon University School of Medicine, Tokyo, Japan -
Department of Internal Medicine, Sakuboukai Tokiwadaigeka Hospital, Tokyo, Japan.
Minerva Urol Nefrol. 2017 Apr;69(2):195-200. doi: 10.23736/S0393-2249.16.02500-5. Epub 2015 Dec 3.
Adipocytokines are associated with the pathophysiology of type 2 diabetes (T2DM).
We analyzed the relationship between levels of the plasma C1q/tumor necrosis factor-related protein 9 (CTRP9) and other adipocytokines or the endothelial function in patients with T2DM, and analyzed their trending manner.
CTRP9 was detected in plasma from 14 out of a total of 28 patients. The values were not normally distributed. In comparing between groups in which CTRP9 was or was not detected, there were statistically significant differences in the high molecular weight adiponectin (HAN) and the urinary albumin/creatinine ratio (ACR). This indicates that both CTRP9 and HAN reflect the pathophysiology of renal involvement in T2DM. HAN correlated with Body Mass Index, ACR, and homeostasis model assessment of insulin resistance. However, CTRP9 did not correlate with HAN or any other parameters.
CTRP9 independently trends in a different manner from HAN, and may reflect diabetic renal vascular risk in association with atherosclerosis and abnormal glucose metabolism besides of impaired vaso-relaxation in patients with T2DM.
脂肪细胞因子与2型糖尿病（T2DM）的病理生理学相关。
我们分析了T2DM患者血浆C1q/肿瘤坏死因子相关蛋白9（CTRP9）水平与其他脂肪细胞因子或内皮功能之间的关系，并分析了它们的变化趋势。
在总共28例患者中，有14例患者的血浆中检测到CTRP9。这些值呈非正态分布。在比较检测到CTRP9和未检测到CTRP9的组之间，高分子量脂联素（HAN）和尿白蛋白/肌酐比值（ACR）存在统计学显著差异。这表明CTRP9和HAN均反映了T2DM患者肾脏受累的病理生理学。HAN与体重指数、ACR以及胰岛素抵抗的稳态模型评估相关。然而，CTRP9与HAN或任何其他参数均无相关性。
CTRP9的变化趋势与HAN不同，且独立于HAN，除了T2DM患者血管舒张功能受损外，CTRP9可能还反映了与动脉粥样硬化和葡萄糖代谢异常相关的糖尿病肾血管风险。
