Miyazato Minoru, Tohyama Kazuyo, Touyama Masato, Nakamura Hiroshi, Oshiro Takuma, Ueda Shinichiro, Saito Seiichi
Department of Urology, Graduate School of Medicine, University of the Ryukyus, Okinawa, Japan.
Nakamura Clinic, Okinawa, Japan.
Neurourol Urodyn. 2017 Feb;36(2):376-379. doi: 10.1002/nau.22936. Epub 2015 Dec 3.
The aim of this study was to identify the clinical features of patients with obstructive sleep apnea syndrome (OSAS) and investigate the impact of continuous positive airway pressure (CPAP) treatment on nocturnal urine volume.
This study enrolled 53 patients with moderate-to-severe OSAS and an apnea-hypoxia index of >20/hr. Data were collected on serum brain natriuretic peptide (BNP) level, International Prostate Symptom Score-Quality of Life (IPSS-QOL) score, Overactive Bladder Symptom Score (OABSS), International Consultation on Incontinence Modular Questionnaire-Nocturia QOL (ICIQ-NQOL) score, Epworth Sleepiness Scale (ESS) score, and the frequency volume chart. Only patients who continued CPAP treatment for 3 months were included in the analysis.
In total, 40 patients (33 men and 7 women) completed the study (75.5%). The mean age was 56.9 years. The night-time frequency to void was significantly decreased from 2.1 to 1.2 after CPAP treatment (P < 0.01). The mean scores as assessed by ESS, IPSS-QOL, OABSS, and ICIQ-NQOL significantly improved after CPAP (P < 0.01). The mean diastolic blood pressure significantly decreased after CPAP treatment. However, there was no significant change in the BNP level before and after CPAP treatment. In the frequency volume chart, hours of undisturbed sleep, total nocturnal voided volume, and nocturnal polyuria index significantly improved after CPAP treatment (P < 0.05). However, 24-hr voided volume and mean voided volume during night-time did not change after CPAP treatment.
CPAP treatment decreases night-time urinary frequency by reducing nocturnal urine production and improves QOL in patients with OSAS. Neurourol. Urodynam. 36:376-379, 2017. © 2015 Wiley Periodicals, Inc.
本研究旨在确定阻塞性睡眠呼吸暂停综合征（OSAS）患者的临床特征，并探讨持续气道正压通气（CPAP）治疗对夜间尿量的影响。
本研究纳入了53例中重度OSAS且呼吸暂停低氧指数>20次/小时的患者。收集了血清脑钠肽（BNP）水平、国际前列腺症状评分-生活质量（IPSS-QOL）评分、膀胱过度活动症状评分（OABSS）、国际尿失禁咨询模块化问卷-夜尿生活质量（ICIQ-NQOL）评分、爱泼沃斯嗜睡量表（ESS）评分以及排尿频率-尿量图表的数据。仅将持续CPAP治疗3个月的患者纳入分析。
共有40例患者（33例男性和7例女性）完成了研究（75.5%）。平均年龄为56.9岁。CPAP治疗后夜间排尿频率从2.1次显著降至1.2次（P<0.01）。CPAP治疗后，ESS、IPSS-QOL、OABSS和ICIQ-NQOL评估的平均评分显著改善（P<0.01）。CPAP治疗后平均舒张压显著降低。然而，CPAP治疗前后BNP水平无显著变化。在排尿频率-尿量图表中，CPAP治疗后无干扰睡眠小时数、夜间总尿量和夜间多尿指数显著改善（P<0.05）。然而，CPAP治疗后24小时尿量和夜间平均尿量没有变化。
CPAP治疗通过减少夜间尿量生成降低夜间排尿频率，并改善OSAS患者的生活质量。《神经泌尿学与尿动力学》36:376 - 379，2017年。©2015威利期刊公司
