Ashikari Asuka, Miyazato Minoru, Nakamura Koshi, Yamashiro Kiyoto, Nakamura Takehiro, Uema Tsugumi, Uehara Moriyuki, Masuzaki Hiroaki, Saito Seiichi, Maeda Shiro, Ishida Hajime, Matsushita Masayuki
Department of Urology, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan.
Department of Systems Physiology, Graduate School of Medicine, University of the Ryukyus, Nishihara 903-0215, Japan.
Metabolites. 2022 May 23;12(5):468. doi: 10.3390/metabo12050468.
(1) Background: Evidence has accumulated regarding the etiology of lower urinary tract symptoms associated with obesity and metabolic syndrome. Therefore, the present study aimed to identify which subjectively and objectively measured voiding parameters were associated with obesity in a community-based population. (2) Methods: Voiding parameters on a self-administered questionnaire and a digital self-health monitoring system for urine excretion (s-HMSU) were compared between participants with and without obesity, defined as a body mass index ≥ 25 kg/m2 (n = 30 and 29, respectively), from a community in Okinawa, Japan. Logistic regression analysis was employed to calculate the odds ratios of abnormalities in voiding parameters for the obese group, with the non-obese group serving as a reference. (3) Results: The obese group had odds ratios of 5.17 (95% confidence interval: 1.33−20.0) for shortened hours of undisturbed sleep (<302 min) by s-HMSU and 7.65 (1.88−31.1) for nighttime urinary frequency by a questionnaire after adjusting for age and sex. In addition, the obese group had an adjusted odds ratio of 2.27 (0.76−6.78) for decreased maximum bladder capacity (<212 mL) by s-HMSU. (4) Conclusion: the results of the present study suggest that nocturia and shortened hours of undisturbed sleep are signs of obesity.
(1) 背景：关于肥胖和代谢综合征相关下尿路症状的病因，已有越来越多的证据。因此，本研究旨在确定在社区人群中，哪些主观和客观测量的排尿参数与肥胖相关。(2) 方法：在日本冲绳的一个社区中，比较了体重指数≥25kg/m²的肥胖参与者（n = 30）和非肥胖参与者（n = 29）在自我管理问卷和尿液排泄数字自我健康监测系统（s-HMSU）上的排尿参数。采用逻辑回归分析计算肥胖组排尿参数异常的比值比，以非肥胖组作为对照。(3) 结果：在调整年龄和性别后，肥胖组通过s-HMSU测量的无干扰睡眠时长缩短（<302分钟）的比值比为5.17（95%置信区间：1.33−20.0），通过问卷测量的夜间尿频的比值比为7.65（1.88−31.1）。此外，肥胖组通过s-HMSU测量的最大膀胱容量降低（<212mL）的调整后比值比为2.27（0.76−6.78）。(4) 结论：本研究结果表明，夜尿症和无干扰睡眠时长缩短是肥胖的迹象。
