运动神经元病功能磁共振成像研究的系统评价与荟萃分析
A Systematic Review and Meta-Analysis of the Functional MRI Investigation of Motor Neuron Disease.
作者信息
Shen Dongchao, Cui Liying, Cui Bo, Fang Jia, Li Dawei, Ma Junfang
机构信息
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China.
Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing , China ; Neuroscience Center, Chinese Academy of Medical Sciences , Beijing , China.
出版信息
Front Neurol. 2015 Nov 24;6:246. doi: 10.3389/fneur.2015.00246. eCollection 2015.
BACKGROUND
To assess the use of functional magnetic resonance imaging (fMRI) in motor neuron disease (MND), a systematic review and voxelwise meta-analysis of studies comparing brain activity in patients with MND and in healthy controls was conducted to identify common findings across studies.
METHODS
A search for related papers published in English and Chinese was performed in Ovid Medline, Pubmed, and Embase database. Voxelwise meta-analysis was performed using signed differential mapping.
RESULTS
The findings from 55 fMRI studies on MND were tabulated, and some common findings were discussed in further details.
CONCLUSION
These findings are preliminary, sometimes even contradictory, and do not allow a complete understanding of the functional alterations in MND. However, we documented reliable findings that MND is not confined to the motor system, but is a multisystem disorder involving extra-motor cortex areas, causing cognitive dysfunction and deficits in socioemotional and sensory processing pathways.
背景
为评估功能磁共振成像（fMRI）在运动神经元病（MND）中的应用，我们进行了一项系统评价和体素水平的荟萃分析，比较MND患者与健康对照者的脑活动，以确定各研究中的共同发现。
方法
在Ovid Medline、Pubmed和Embase数据库中检索以英文和中文发表的相关论文。使用符号差异映射进行体素水平的荟萃分析。
结果
汇总了55项关于MND的fMRI研究结果，并对一些共同发现进行了更详细的讨论。
结论
这些发现是初步的，有时甚至相互矛盾，无法完全理解MND中的功能改变。然而，我们记录了可靠的发现，即MND不仅局限于运动系统，而是一种涉及运动外皮层区域的多系统疾病，会导致认知功能障碍以及社会情感和感觉处理通路的缺陷。
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