Terasaka K, Yamaguchi R, Matsuo K, Yamazaki A, Nagai S, Yamada T
Research Institute for Microbial Diseases, Osaka University, Japan.
FEMS Microbiol Lett. 1989 Apr;49(2-3):273-6. doi: 10.1016/0378-1097(89)90052-9.
The extracellular protein MPB70 is a heat-stable immunogenic protein which was found in the culture filtrate of Mycobacterium bovis BCG Japanese. We determined the complete nt and aa sequences of MPB70 and correlated with the previously reported data. The N-terminal sequence revealed that the signal peptide (SP) consisted of 30 aa and that the mature protein had 163 aa with a molecular weight of 16,305. The SP displayed a characteristic feature of an Ala-rich property which would be efficient in a SP function.
细胞外蛋白MPB70是一种热稳定的免疫原性蛋白，它是在日本卡介苗的培养滤液中发现的。我们测定了MPB70的完整核苷酸和氨基酸序列，并与先前报道的数据进行了关联。N端序列显示信号肽（SP）由30个氨基酸组成，成熟蛋白有163个氨基酸，分子量为16305。该信号肽具有富含丙氨酸的特征，这在信号肽功能中可能是有效的。
