Chawner J A, Gilbert P
Department of Pharmacy, University of Manchester, UK.
J Appl Bacteriol. 1989 Mar;66(3):243-52. doi: 10.1111/j.1365-2672.1989.tb02475.x.
A comparative study of the growth inhibitory and bactericidal activities of two related bisbiguanide antiseptics, alexidine and chorhexidine is reported. Whilst overall bactericidal activities and MICs were similar, alexidine was more rapid in its action and it is suggested that (1) it might possess additional targets at the cell envelope to chlorhexidine, and (2) the nature of the interaction at the cytoplasmic membrane for the two compounds differs.
本文报道了两种相关的双胍类防腐剂——阿来西定和洗必泰的生长抑制及杀菌活性的比较研究。虽然总体杀菌活性和最低抑菌浓度相似，但阿来西定的作用更快，研究表明：（1）与洗必泰相比，它可能在细胞包膜上具有额外的作用靶点；（2）两种化合物在细胞质膜上的相互作用性质不同。
