Roberts W R, Addy M
J Clin Periodontol. 1981 Jun;8(3):213-9. doi: 10.1111/j.1600-051x.1981.tb02032.x.
A blind crossover trial was carried out to compare the effects of a 0.2% chlorhexidine gluconate mouthrinse and a 0.035% alexidine mouthrinse on plaque accumulation and salivary bacteria in a group of volunteers. The subjects refrained from all forms of oral hygiene during two 10-day periods and rinsed twice a day with the mouthwash randomly allocated to the respective period. Prerinse, day 4 and day 10 total salivary aerobic and anaerobic bacterial counts were determined during each period. Plaque scores were recorded at the end of each 10-day period. Significantly more plaque accumulated in subjects rinsing with alexidine when compared with chlorhexidine. Significant and comparable reductions in salivary bacterial counts were observed with both chlorhexidine and alexidine on day 4 and day 10 when compared with pre-rinse counts. Although at the concentrations used alexidine was less effective than chlorhexidine, it may be of value as a short-term adjunct to oral hygiene.
进行了一项双盲交叉试验，以比较0.2%葡萄糖酸氯己定漱口水和0.035%阿来西定漱口水对一组志愿者牙菌斑积聚和唾液细菌的影响。受试者在两个10天的时间段内停止所有形式的口腔卫生措施，并在各自的时间段内每天用随机分配的漱口水漱口两次。在每个时间段内，测定预漱口、第4天和第10天的唾液需氧菌和厌氧菌总数。在每个10天时间段结束时记录牙菌斑评分。与使用氯己定的受试者相比，使用阿来西定的受试者牙菌斑积聚明显更多。与预漱口时的计数相比，在第4天和第10天，氯己定和阿来西定都观察到唾液细菌计数显著且相当程度的减少。尽管在所使用的浓度下，阿来西定的效果不如氯己定，但作为口腔卫生的短期辅助手段可能具有价值。
