Ebrahimi Azizollah, Hemati Majid, Habibian Dehkordi Saeed, Bahadoran Shahab, Khoshnood Sheida, Khubani Shahin, Dokht Faraj Mahdi, Hakimi Alni Reza
School of Veterinary Science, Shahrekord University, Shahrekord, IR Iran.
Para-Veterinary Sciences, Bu-Ali Sina University, Hamedan, IR Iran.
Jundishapur J Nat Pharm Prod. 2014 Apr 14;9(2):e14298. doi: 10.17795/jjnpp-14298. eCollection 2014 May.
To study chlorhexidine digluconate disinfectant effects on planktonic growth and biofilm formation in some bacterial field isolates from animals.
The current study investigated chlorhexidine digluconate effects on planktonic growth and biofilm formation in some field isolates of veterinary bacterial pathogens.
Forty clinical isolates of Escherichia coli, Salmonella serotypes, Staphylococcus. aureus and Streptococcus agalactiae (10 isolates for each) were examined for chlorhexidine digluconate effects on biofilm formation and planktonic growth using microtiter plates. In all of the examined strains in the presence of chlorhexidine digluconate, biofilm development and planktonic growth were affected at the same concentrations of the disinfectant.
Chlorhexidine digluconate inhibited the planktonic growth of different bacterial species at sub-MICs. But they were able to induce biofilm development of the E. coli, Salmonella spp., S. aureus and Str. agalactiae strains.
Bacterial resistance against chlorhexidine is increasing. Sub-MIC doses of chlorhexidine digluconate can stimulate the formation of biofilm strains.
研究葡萄糖酸洗必泰对动物源部分细菌野外分离株浮游生长及生物膜形成的消毒效果。
本研究调查葡萄糖酸洗必泰对一些兽医细菌病原体野外分离株浮游生长及生物膜形成的影响。
使用微量滴定板检测40株临床分离的大肠杆菌、沙门氏菌血清型、金黄色葡萄球菌和无乳链球菌（每种10株），观察葡萄糖酸洗必泰对生物膜形成和浮游生长的影响。在所有检测菌株中，在相同浓度的消毒剂存在下，生物膜形成和浮游生长均受到葡萄糖酸洗必泰的影响。
葡萄糖酸洗必泰在亚最小抑菌浓度下抑制不同细菌种类的浮游生长。但它们能够诱导大肠杆菌、沙门氏菌属、金黄色葡萄球菌和无乳链球菌菌株形成生物膜。
细菌对洗必泰的耐药性正在增加。亚最小抑菌浓度的葡萄糖酸洗必泰剂量可刺激生物膜菌株的形成。
