Suppr超能文献

天然产物药物发现的新黄金时代。

A New Golden Age of Natural Products Drug Discovery.

作者信息

Shen Ben

机构信息

Department of Chemistry, The Scripps Research Institute, Jupiter, FL 33458, USA; Department of Molecular Therapeutics, The Scripps Research Institute, Jupiter, FL 33458, USA; Natural Products Library Initiative at The Scripps Research Institute, The Scripps Research Institute, Jupiter, FL 33458, USA; Xiangya International Academy of Translational Medicine, Central South University, Changsha, Hunan 410013, China.

出版信息

Cell. 2015 Dec 3;163(6):1297-300. doi: 10.1016/j.cell.2015.11.031.

Abstract

The 2015 Nobel Prize in Physiology or Medicine has been awarded to William C. Campbell, Satoshi Omura, and Youyou Tu for the discovery of avermectins and artemisinin, respectively, therapies that revolutionized the treatment of devastating parasite diseases. With the recent technological advances, a New Golden Age of natural products drug discovery is dawning.

摘要

2015年诺贝尔生理学或医学奖授予威廉·C·坎贝尔、大村智和屠呦呦,分别表彰他们发现了阿维菌素和青蒿素,这两种疗法彻底改变了对严重寄生虫病的治疗。随着近期技术的进步,天然产物药物发现的新黄金时代正在到来。

相似文献

1
A New Golden Age of Natural Products Drug Discovery.
Cell. 2015 Dec 3;163(6):1297-300. doi: 10.1016/j.cell.2015.11.031.
2
Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine.
Proc Natl Acad Sci U S A. 2015 Dec 29;112(52):15773-6. doi: 10.1073/pnas.1520952112. Epub 2015 Dec 22.
3
Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin.
Trends Parasitol. 2015 Dec;31(12):605-607. doi: 10.1016/j.pt.2015.10.008. Epub 2015 Nov 6.
4
Honoring antiparasitics: The 2015 Nobel Prize in Physiology or Medicine.
Biomed J. 2016 Apr;39(2):93-7. doi: 10.1016/j.bj.2016.04.002. Epub 2016 Jun 6.
5
A Brief History of Qinghaosu.
Trends Parasitol. 2015 Dec;31(12):607-610. doi: 10.1016/j.pt.2015.10.010.
6
[Avermectin, from winning the Nobel Prize to "innovation in China"].
Wei Sheng Wu Xue Bao. 2016 Mar 4;56(3):543-58.
7
The discovery of artemisinin and the Nobel Prize in Physiology or Medicine.
Sci China Life Sci. 2015 Nov;58(11):1175-9. doi: 10.1007/s11427-015-4948-7.
8
Celebrating the 2015 Nobel Prize in Physiology or Medicine of Dr Satoshi Ōmura.
J Antibiot (Tokyo). 2016 Jan;69(1):1. doi: 10.1038/ja.2015.113. Epub 2015 Oct 21.
9
Ivermectin - Old Drug, New Tricks?
Trends Parasitol. 2017 Jun;33(6):463-472. doi: 10.1016/j.pt.2017.02.004. Epub 2017 Mar 9.
10
Ivermectin: enigmatic multifaceted 'wonder' drug continues to surprise and exceed expectations.
J Antibiot (Tokyo). 2017 May;70(5):495-505. doi: 10.1038/ja.2017.11. Epub 2017 Feb 15.

引用本文的文献

1
From Mushrooms to Molecules: Exploring Depsidones in for Antioxidant and Anticancer Applications.
Molecules. 2025 Sep 8;30(17):3650. doi: 10.3390/molecules30173650.
3
Biosynthesis of Biphenomycin-like Macrocyclic Peptides by Formation and Cross-Linking of -Tyrosines.
J Am Chem Soc. 2025 Jul 9;147(27):23781-23796. doi: 10.1021/jacs.5c06044. Epub 2025 Jun 26.
4
Diarylpentanoid, a curcumin analog, inhibits malignant meningioma growth in both and models.
World J Exp Med. 2025 Jun 20;15(2):102897. doi: 10.5493/wjem.v15.i2.102897.
5
Biosynthesis of Macrocyclic Peptides by Formation and Crosslinking of -Tyrosines.
bioRxiv. 2025 Apr 8:2025.04.04.647296. doi: 10.1101/2025.04.04.647296.
7
iCASRED, a scarless DNA editing tool in for high-efficiency engineering of natural product biosynthetic gene clusters.
Synth Syst Biotechnol. 2025 Mar 20;10(3):751-763. doi: 10.1016/j.synbio.2025.03.008. eCollection 2025 Sep.
8
4(3)-Quinazolinone: A Natural Scaffold for Drug and Agrochemical Discovery.
Int J Mol Sci. 2025 Mar 10;26(6):2473. doi: 10.3390/ijms26062473.
9
Flavonoids as Promising Natural Compounds for Combating Bacterial Infections.
Int J Mol Sci. 2025 Mar 10;26(6):2455. doi: 10.3390/ijms26062455.
10
Synthetic Biology in Natural Product Biosynthesis.
Chem Rev. 2025 Apr 9;125(7):3814-3931. doi: 10.1021/acs.chemrev.4c00567. Epub 2025 Mar 21.

本文引用的文献

1
Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.
J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):261-76. doi: 10.1007/s10295-015-1671-0. Epub 2015 Aug 29.
2
Ivermectin: panacea for resource-poor communities?
Trends Parasitol. 2014 Sep;30(9):445-55. doi: 10.1016/j.pt.2014.07.005. Epub 2014 Aug 12.
3
Mass spectrometry of natural products: current, emerging and future technologies.
Nat Prod Rep. 2014 Jun;31(6):718-29. doi: 10.1039/c4np00044g. Epub 2014 May 7.
4
Chemical-biogeographic survey of secondary metabolism in soil.
Proc Natl Acad Sci U S A. 2014 Mar 11;111(10):3757-62. doi: 10.1073/pnas.1318021111. Epub 2014 Feb 18.
5
High-level semi-synthetic production of the potent antimalarial artemisinin.
Nature. 2013 Apr 25;496(7446):528-32. doi: 10.1038/nature12051. Epub 2013 Apr 10.
6
Natural products as sources of new drugs over the 30 years from 1981 to 2010.
J Nat Prod. 2012 Mar 23;75(3):311-35. doi: 10.1021/np200906s. Epub 2012 Feb 8.
7
The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine.
Nat Med. 2011 Oct 11;17(10):1217-20. doi: 10.1038/nm.2471.
8
Drug discovery and natural products: end of an era or an endless frontier?
Science. 2009 Jul 10;325(5937):161-5. doi: 10.1126/science.1168243.
9
The life and times of ivermectin - a success story.
Nat Rev Microbiol. 2004 Dec;2(12):984-9. doi: 10.1038/nrmicro1048.
10

文献AI研究员

20分钟写一篇综述,助力文献阅读效率提升50倍。

立即体验

用中文搜PubMed

大模型驱动的PubMed中文搜索引擎

马上搜索

文档翻译

学术文献翻译模型,支持多种主流文档格式。

立即体验