Khiljee Sonia, Rehman Nisarur, Khiljee Tanzila, Loebenberg Raimar, Ahmad Rao Saeed
The Islamia University of Bahawalpur, Pakistan / Institute of Pharmaceutical Sciences, University of Veterinary and animal Sciences, Lahore, Pakistan / Faculty of Pharmacy & Pharmaceutical Sciences, University of Alberta, Edmonton, Canada.
The Islamia University of Bahawalpur, Pakistan / Department of Pharmaceutical Sciences, COMSATS Institute of Information Technology, Abbottabad, Pakistan.
Pak J Pharm Sci. 2015 Nov;28(6):2001-7.
Eczema is characterized by itching, lichenification, scaling, oedema and erythema. Current management strategies include corticosteroids, which are limited due to side effects. Many herbal remedies are used traditionally but unfortunately have not been validated in controlled clinical trials. Three popular traditional treatments of eczema include Indian pennywort, Walnut and Turmeric. In this study three topical formulations (micro emulsion, gel and ointment) were prepared from extracts of Indian pennywort, Walnut and Turmeric. These formulations were monitored for stability for a period of three months. Controlled clinical trials were conducted on 360 eczema patients. Clinical parameters observed were degree of erythema, oedema, scaling, itching and lichenification. Effects of each formulation on these clinical parameters were compared with placebo formulations. Micro emulsion formulations in all cases proved to be more effective in reducing semi quantitative scores of erythema and oedema. Itching was relieved more by gel formulation. The ointment showed more efficacy towards scaling and lichenification. Comparison of the effects of placebo and the specific formulations was performed by chi-square statistics and found to be highly significant. In summary it is concluded that all the formulations could be used as promising source for treatment of eczema.
湿疹的特征为瘙痒、苔藓化、脱屑、水肿和红斑。目前的治疗策略包括使用皮质类固醇，但由于副作用其应用受到限制。传统上使用许多草药疗法，但遗憾的是这些疗法尚未在对照临床试验中得到验证。三种常见的湿疹传统治疗方法包括积雪草、核桃和姜黄。在本研究中，用积雪草、核桃和姜黄的提取物制备了三种外用制剂（微乳剂、凝胶和软膏）。对这些制剂进行了为期三个月的稳定性监测。对360名湿疹患者进行了对照临床试验。观察的临床参数有红斑程度、水肿、脱屑、瘙痒和苔藓化。将每种制剂对这些临床参数的作用与安慰剂制剂进行比较。在所有情况下，微乳剂制剂在降低红斑和水肿的半定量评分方面被证明更有效。凝胶制剂对瘙痒的缓解作用更强。软膏对脱屑和苔藓化显示出更大的疗效。通过卡方统计对安慰剂和特定制剂的效果进行比较，发现差异具有高度显著性。总之，得出的结论是，所有这些制剂都可作为治疗湿疹的有前景的来源。
