Stefanov Stefan R, Andonova Velichka Y
Department of Pharmaceutical Technologies, Faculty of Pharmacy, Medical University of Varna, 9002 Varna, Bulgaria.
Pharmaceuticals (Basel). 2021 Oct 26;14(11):1083. doi: 10.3390/ph14111083.
The multifunctional role of the human skin is well known. It acts as a sensory and immune organ that protects the human body from harmful environmental impacts such as chemical, mechanical, and physical threats, reduces UV radiation effects, prevents moisture loss, and helps thermoregulation. In this regard, skin disorders related to skin integrity require adequate treatment. Lipid nanoparticles (LN) are recognized as promising drug delivery systems (DDS) in treating skin disorders. Solid lipid nanoparticles (SLN) together with nanostructured lipid carriers (NLC) exhibit excellent tolerability as these are produced from physiological and biodegradable lipids. Moreover, LN applied to the skin can improve stability, drug targeting, occlusion, penetration enhancement, and increased skin hydration compared with other drug nanocarriers. Furthermore, the features of LN can be enhanced by inclusion in suitable bases such as creams, ointments, gels (i.e., hydrogel, emulgel, bigel), lotions, etc. This review focuses on recent developments in lipid nanoparticle systems and their application to treating skin diseases. We point out and consider the reasons for their creation, pay attention to their advantages and disadvantages, list the main production techniques for obtaining them, and examine the place assigned to them in solving the problems caused by skin disorders.
人类皮肤的多功能作用众所周知。它作为一种感觉和免疫器官，保护人体免受化学、机械和物理威胁等有害环境影响，减少紫外线辐射的影响，防止水分流失，并有助于体温调节。在这方面，与皮肤完整性相关的皮肤疾病需要适当治疗。脂质纳米颗粒（LN）被认为是治疗皮肤疾病的有前景的药物递送系统（DDS）。固体脂质纳米颗粒（SLN）与纳米结构脂质载体（NLC）表现出优异的耐受性，因为它们是由生理性和可生物降解的脂质制成的。此外，与其他药物纳米载体相比，应用于皮肤的LN可以提高稳定性、药物靶向性、封闭性、促进渗透并增加皮肤水合作用。此外，通过将LN包含在合适的基质如乳膏、软膏、凝胶（即水凝胶、乳化凝胶、双凝胶）、洗剂等中，可以增强其特性。本综述重点关注脂质纳米颗粒系统的最新进展及其在治疗皮肤疾病中的应用。我们指出并考虑其产生的原因，关注其优缺点，列出获得它们的主要生产技术，并研究它们在解决皮肤疾病引起的问题中所占据的地位。
