Jones Virginia A, Patel Payal M, Wilson Claire, Wang Hongnan, Ashack Kurt A
Department of Dermatology, University of Illinois at Chicago, Chicago, Illinois.
Department of Mathematics, Statistics and Computer Science, University of Illinois at Chicago, Chicago, Illinois.
JAAD Int. 2020 Dec 26;2:76-93. doi: 10.1016/j.jdin.2020.11.001. eCollection 2021 Mar.
Complementary and alternative medicine (CAM) treatments are growing in popularity as alternative treatments for common skin conditions.
To perform a systematic review and meta-analysis to determine the tolerability and treatment response to CAM treatments in acne, atopic dermatitis (AD), and psoriasis.
PubMed/Medline and Embase databases were searched to identify eligible studies measuring the effects of CAM in acne, AD, and psoriasis. Effect size with 95% confidence interval (CI) was estimated using the random-effect model.
The search yielded 417 articles; 40 studies met the inclusion criteria. The quantitative results of CAM treatment showed a standard mean difference (SMD) of 3.78 (95% CI [-0.01, 7.57]) and 0.58 (95% CI [-6.99, 8.15]) in the acne total lesion count, a SMD of -0.70 (95% CI [-1.19, -0.21]) in the eczema area and severity index score and a SMD of 0.94 (95% CI [-0.83, 2.71]) in the scoring of atopic dermatitis score for AD, and a SMD of 3.04 (95% CI [-0.35, 6.43]) and 5.16 (95% CI [-0.52, 10.85]) in the Psoriasis Area Severity Index score for psoriasis.
Differences between the study designs, sample sizes, outcome measures, and treatment durations limit the generalizability of data.
Based on our quantitative findings we conclude that there is insufficient evidence to support the efficacy and the recommendation of CAM for acne, AD, and psoriasis.
补充和替代医学（CAM）疗法作为常见皮肤病的替代治疗方法越来越受欢迎。
进行系统评价和荟萃分析，以确定CAM疗法治疗痤疮、特应性皮炎（AD）和银屑病的耐受性及治疗反应。
检索PubMed/Medline和Embase数据库，以识别测量CAM对痤疮、AD和银屑病影响的合格研究。使用随机效应模型估计效应量及95%置信区间（CI）。
检索得到417篇文章；40项研究符合纳入标准。CAM治疗的定量结果显示，痤疮总皮损计数的标准均差（SMD）为3.78（95%CI[-0.01,7.57]）和0.58（95%CI[-6.99,8.15]），湿疹面积和严重程度指数评分的SMD为-0.70（95%CI[-1.19,-0.21]），AD的特应性皮炎评分的SMD为0.94（95%CI[-0.83,2.71]），银屑病的银屑病面积严重程度指数评分的SMD为3.04（95%CI[-0.35,6.43]）和5.16（95%CI[-0.52,10.85]）。
研究设计、样本量、结局指标和治疗持续时间之间的差异限制了数据的可推广性。
基于我们的定量研究结果，我们得出结论，没有足够的证据支持CAM对痤疮、AD和银屑病的疗效及推荐使用。
