Floriani Irene, Quaranta Luciano, Rulli Eliana, Katsanos Andreas, Varano Luigi, Frezzotti Paolo, Rossi Gemma C M, Carmassi Luciana, Rolle Teresa, Ratiglia Roberto, Gandolfi Stefano, Fossarello Maurizio, Uva Maurizio, Hollander Lital, Poli Davide, Grignolo Federico
IRCCS Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
University of Brescia, Brescia, Italy.
Acta Ophthalmol. 2016 Aug;94(5):e278-e286. doi: 10.1111/aos.12890. Epub 2015 Nov 19.
As a progressive condition, glaucoma may impair health-related quality of life (HRQoL), due to vision loss and other factors. This study evaluated HRQoL in a cohort of patients treated for primary open-angle glaucoma (POAG) and assessed its association with clinical features.
This was an Italian, multicentre, cross-sectional, observational study with the subgroup of newly diagnosed patients with POAG prospectively followed up for one year. Patients with previous or new diagnosis (or strong clinical suspicion) of POAG aged >18 years were considered eligible. Information was collected on demographic characteristics, medical history, clinical presentation and POAG treatments. HRQoL was measured using the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and Glaucoma Symptom Scale (GSS). Subscale and total scores were obtained and a Pearson correlation coefficient between instruments' scores calculated.
A total of 3227 patients were enrolled from 2012 to 2013 and 3169 were analysed. Mean age was 66.9 years. A total of 93.8% had a previous diagnosis (median duration: 8.0 years). Median values for mean deviation and pattern standard deviation were 3.9 and 3.6 dB, respectively. Mean scores on most subscales of the NEI-VFQ-25 exceeded 75.0 and mean GSS subscale scores ranged between 70.8 and 79.7 (with a total mean score of 74.8). HRQoL scores on both scales were significantly inversely associated with POAG severity.
In this large sample of Italians treated for POAG, disease severity was limited and HRQoL scores were high. QoL decreased with advancing disease severity. These findings confirm the role of vision loss in impairing QoL in POAG, underlying the importance of timely detection and appropriate treatment.
青光眼作为一种渐进性疾病，可能因视力丧失及其他因素而损害与健康相关的生活质量（HRQoL）。本研究评估了一组原发性开角型青光眼（POAG）患者的HRQoL，并评估了其与临床特征的关联。
这是一项意大利的多中心横断面观察性研究，对新诊断的POAG患者亚组进行了为期一年的前瞻性随访。年龄>18岁、既往有POAG诊断或新诊断（或高度临床怀疑）的患者被认为符合条件。收集了人口统计学特征、病史、临床表现和POAG治疗方面的信息。使用25项国家眼科研究所视觉功能问卷（NEI-VFQ-25）和青光眼症状量表（GSS）测量HRQoL。获得了子量表和总分，并计算了两种量表得分之间的Pearson相关系数。
2012年至2013年共纳入3227例患者，分析了3169例。平均年龄为66.9岁。共有93.8%的患者有既往诊断（中位病程：8.0年）。平均偏差和模式标准偏差的中位值分别为3.9和3.6 dB。NEI-VFQ-25大多数子量表的平均得分超过75.0，GSS子量表的平均得分在70.8至79.7之间（总平均得分为74.8）。两种量表的HRQoL得分均与POAG严重程度显著负相关。
在这一大组接受POAG治疗的意大利人中，疾病严重程度有限，HRQoL得分较高。生活质量随疾病严重程度的进展而下降。这些发现证实了视力丧失在损害POAG患者生活质量中的作用，强调了及时检测和适当治疗的重要性。
