IRCCS - Istituto di Ricerche Farmacologiche Mario Negri, Milan, Italy.
DMSS, University of Brescia, Brescia, Italy.
Sci Rep. 2018 Jan 12;8(1):619. doi: 10.1038/s41598-017-19113-z.
The aim of this study was to examine the relationship between visual field (VF) loss, vision-related quality of life (QoL) and glaucoma-related symptoms in a large cohort of primary open angle glaucoma (POAG) patients. POAG patients with or without VF defects or "glaucoma suspect" patients were considered eligible. QoL was assessed using the validated versions of the 25-item National Eye Institute Visual Function Questionnaire (NEI-VFQ-25) and glaucoma-related symptoms were assessed using the Glaucoma Symptom Scale (GSS). Patients were classified as having VF damage in one eye (VFD-1), both eyes (VFD-2), or neither eye (VFD-0). 3227 patients were enrolled and 2940 were eligible for the analysis. 13.4% of patients were classified in the VFD-0, 23.7% in the VFD-1, and 62.9% in the VFD-2 group. GSS visual symptoms domain (Func-4) and GSS non-visual symptoms domain (Symp-6) scores were similar for the VFD-0 and VFD-1 groups (p = 0.133 and p = 0.834 for Func-4 and Symp-6, respectively). VFD-0 group had higher scores than VFD-2 both in Func-4 (p < 0.001) and Symp-6 domains (p = 0.035). Regarding the NEI-VFQ-25, our data demonstrated that bilateral VF defects are associated with vision-related QoL deterioration, irrespective of visual acuity.
本研究旨在探讨大样本原发性开角型青光眼（POAG）患者的视野（VF）丧失、与视觉相关的生活质量（QoL）和青光眼相关症状之间的关系。纳入具有或不具有 VF 缺损的 POAG 患者或“青光眼疑似”患者。使用经过验证的 25 项国家眼科研究所视觉功能问卷（NEI-VFQ-25）版本评估 QoL，使用青光眼症状量表（GSS）评估青光眼相关症状。患者被分为一眼（VFD-1）、双眼（VFD-2）或无眼（VFD-0）有 VF 损伤。共纳入 3227 例患者，2940 例符合分析条件。13.4%的患者被分类为 VFD-0，23.7%为 VFD-1，62.9%为 VFD-2。VFD-0 和 VFD-1 组的 GSS 视觉症状域（Func-4）和 GSS 非视觉症状域（Symp-6）评分相似（Func-4 和 Symp-6 的 p 值分别为 0.133 和 0.834）。VFD-0 组在 Func-4（p<0.001）和 Symp-6 （p=0.035）两个域的评分均高于 VFD-2。关于 NEI-VFQ-25，我们的数据表明双侧 VF 缺损与与视觉相关的 QoL 恶化有关，而与视力无关。
