Cheng Hui-Chen, Guo Chao-Yu, Chen Yu-Jing, Chen Mei-Ju, Ko Yu-Chieh, Huang Nicole, Liu Catherine Jui-Ling
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
PLoS One. 2016 Sep 30;11(9):e0163123. doi: 10.1371/journal.pone.0163123. eCollection 2016.
To investigate the different impacts on patient-reported vision-related quality of life (pVRQOL) outcomes in patients with primary angle-closure glaucoma(PACG) and primary open-angle glaucoma(POAG).
Prospective cross-sectional study. PACG and POAG patients who had a best-corrected visual acuity(BCVA) in the better eye equal to or better than 20/60, intraocular pressure controlled at or below 25 mmHg and reliable visual field test were invited to participate. The control group included patients with BCVA in the better eye equal to or better than 20/60 and who did not have major eye disease. A validated Taiwanese version of the 25-item National Eye Institute Visual Function Questionnaire (NEI VFQ-25(T)) was performed to assess pVRQOL. The association between each domain of NEI VFQ-25(T) among 3 groups was determined using multivariable linear regression analysis.
A total of 106 PACG, 186 POAG, and 95 controls were enrolled. In multivariable regression analysis of all three groups(PACG/POAG/controls), compared to POAG, PACG showed a weakly positive association with social functioning (R2 = 0.13, β = 0.22, P = 0.04). PACG showed no significantly negative impact on pVRQOL compared to controls. Taking only glaucoma patients into consideration, PACG patients had a higher score on social functioning compared to POAG (R2 = 0.16, β = 0.27, P = 0.01). The results of other domains of NEI VFQ-25(T) between the two groups did not differ significantly(p>0.05).
In patients with controlled disease, the impact of PACG and POAG on most domains of NEI VFQ-25(T) were similar, except for better social functioning in PACG compared to POAG.
探讨原发性闭角型青光眼（PACG）和原发性开角型青光眼（POAG）患者对患者报告的视力相关生活质量（pVRQOL）结果的不同影响。
前瞻性横断面研究。邀请最佳矫正视力（BCVA）较好眼等于或优于20/60、眼压控制在25 mmHg及以下且视野检查可靠的PACG和POAG患者参与。对照组包括较好眼BCVA等于或优于20/60且无主要眼病的患者。采用经过验证的25项台湾版美国国立眼科研究所视觉功能问卷（NEI VFQ - 25(T)）评估pVRQOL。使用多变量线性回归分析确定三组中NEI VFQ - 25(T)各领域之间的关联。
共纳入106例PACG患者、186例POAG患者和95例对照者。在对所有三组（PACG/POAG/对照者）进行的多变量回归分析中，与POAG相比，PACG与社会功能呈弱正相关（R2 = 0.13，β = 0.22，P = 0.04）。与对照者相比，PACG对pVRQOL无显著负面影响。仅考虑青光眼患者时，PACG患者的社会功能得分高于POAG患者（R2 = 0.16，β = 0.27，P = 0.01）。两组之间NEI VFQ - 25(T)其他领域的结果无显著差异（p>0.05）。
在疾病得到控制的患者中，PACG和POAG对NEI VFQ - 25(T)大多数领域的影响相似，但PACG的社会功能优于POAG。
