Muyangwa Musalwa, Martynova Ekaterina V, Khaiboullina Svetlana F, Morzunov Sergey P, Rizvanov Albert A
Institute of Fundamental Medicine and Biology, Kazan Federal University Kazan, Russia.
Institute of Fundamental Medicine and Biology, Kazan Federal University Kazan, Russia ; Nevada Center for Biomedical Research, Reno NV, USA.
Front Microbiol. 2015 Nov 27;6:1326. doi: 10.3389/fmicb.2015.01326. eCollection 2015.
Hantaviruses are the members of the family Bunyaviridae that are naturally maintained in the populations of small mammals, mostly rodents. Most of these viruses can easily infect humans through contact with aerosols or dust generated by contaminated animal waste products. Depending on the particular Hantavirus involved, human infection could result in either hemorrhagic fever with renal syndrome or in Hantavirus cardiopulmonary syndrome. In the past few years, clinical cases of the Hantavirus caused diseases have been on the rise. Understanding structure of the Hantavirus genome and the functions of the key viral proteins are critical for the therapeutic agents' research. This paper gives a brief overview of the current knowledge on the structure and properties of the Hantavirus nucleoprotein and the glycoproteins.
汉坦病毒是布尼亚病毒科的成员，自然存在于小型哺乳动物种群中，主要是啮齿动物。这些病毒大多可通过接触受污染动物排泄物产生的气溶胶或灰尘轻易感染人类。根据所涉及的特定汉坦病毒，人类感染可能导致肾综合征出血热或汉坦病毒心肺综合征。在过去几年中，汉坦病毒引起的疾病临床病例一直在增加。了解汉坦病毒基因组结构和关键病毒蛋白的功能对于治疗药物的研究至关重要。本文简要概述了目前关于汉坦病毒核蛋白和糖蛋白的结构及特性的知识。
