Mishina Yuliya V, Krishna Sanjeev, Haynes Richard K, Meade John C
Department of Microbiology, University of Mississippi Medical Center, Jackson, MI 39216, USA.
Antimicrob Agents Chemother. 2007 May;51(5):1852-4. doi: 10.1128/AAC.01544-06. Epub 2007 Mar 5.
Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.
青蒿素类化合物在低微摩尔浓度范围内可抑制培养的克氏锥虫和布氏罗得西亚锥虫的体外生长。青蒿素还可抑制克氏锥虫膜中钙依赖性ATP酶的活性，提示其作用方式可能是通过膜泵。青蒿素作为这些病原体的化疗选择值得进一步研究。
