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本文引用的文献

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Artemisone--a highly active antimalarial drug of the artemisinin class.青蒿甲醚——一种活性很高的青蒿素类抗疟药物。
Angew Chem Int Ed Engl. 2006 Mar 20;45(13):2082-8. doi: 10.1002/anie.200503071.
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Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6.恶性疟原虫野外分离株对体外蒿甲醚的抗性及SERCA型PfATPase6的点突变
Lancet. 2005 Dec 3;366(9501):1960-3. doi: 10.1016/S0140-6736(05)67787-2.
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Yeast model uncovers dual roles of mitochondria in action of artemisinin.酵母模型揭示线粒体在青蒿素作用中的双重作用。
PLoS Genet. 2005 Sep;1(3):e36. doi: 10.1371/journal.pgen.0010036.
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A single amino acid residue can determine the sensitivity of SERCAs to artemisinins.单个氨基酸残基可决定肌浆网钙ATP酶对青蒿素的敏感性。
Nat Struct Mol Biol. 2005 Jul;12(7):628-9. doi: 10.1038/nsmb947. Epub 2005 Jun 5.
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Artemisinins.青蒿素类
Postgrad Med J. 2005 Feb;81(952):71-8. doi: 10.1136/pgmj.2004.028399.
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Activity of dihydroartemisinin against Leishmania donovani both in vitro and vivo.双氢青蒿素对杜氏利什曼原虫的体内外活性
Chin Med J (Engl). 2004 Aug;117(8):1271-3.
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Antimalarial drug toxicity: a review.抗疟药毒性：综述
Drug Saf. 2004;27(1):25-61. doi: 10.2165/00002018-200427010-00003.
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Infection by Trypanosoma cruzi metacyclic forms deficient in gp82 but expressing a related surface molecule, gp30.由克氏锥虫循环后期型引发的感染，该循环后期型缺乏gp82，但表达一种相关的表面分子gp30。
Infect Immun. 2003 Nov;71(11):6184-91. doi: 10.1128/IAI.71.11.6184-6191.2003.
9
GROWTH AND DIFFERENTIATION IN TRYPANOSOMA CRUZI. I. ORIGIN OF METACYCLIC TRYPANOSOMES IN LIQUID MEDIA.克氏锥虫的生长与分化。一、液体培养基中循环后期锥虫的起源
Rev Inst Med Trop Sao Paulo. 1964 May-Jun;6:93-100.
10
Structure-activity relationships of the antimalarial agent artemisinin. 8. design, synthesis, and CoMFA studies toward the development of artemisinin-based drugs against leishmaniasis and malaria.抗疟药物青蒿素的构效关系。8. 基于青蒿素开发抗利什曼病和疟疾药物的设计、合成及比较分子力场分析研究
J Med Chem. 2003 Sep 25;46(20):4244-58. doi: 10.1021/jm030181q.

青蒿素可抑制克氏锥虫和布氏罗得西亚锥虫的体外生长。

Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth.

作者信息

Mishina Yuliya V, Krishna Sanjeev, Haynes Richard K, Meade John C

机构信息

Department of Microbiology, University of Mississippi Medical Center, Jackson, MI 39216, USA.

出版信息

Antimicrob Agents Chemother. 2007 May;51(5):1852-4. doi: 10.1128/AAC.01544-06. Epub 2007 Mar 5.

DOI:10.1128/AAC.01544-06
PMID:17339374
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1855540/
Abstract

Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.

摘要

青蒿素类化合物在低微摩尔浓度范围内可抑制培养的克氏锥虫和布氏罗得西亚锥虫的体外生长。青蒿素还可抑制克氏锥虫膜中钙依赖性ATP酶的活性，提示其作用方式可能是通过膜泵。青蒿素作为这些病原体的化疗选择值得进一步研究。