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生长激素信号传导减弱与蛋氨酸限制：改善代谢健康和延长寿命的干预措施。

Reduced growth hormone signaling and methionine restriction: interventions that improve metabolic health and extend life span.

作者信息

Brown-Borg Holly M

机构信息

Department of Biomedical Sciences, University of North Dakota School of Medicine and Health Sciences, Grand Forks, North Dakota.

出版信息

Ann N Y Acad Sci. 2016 Jan;1363:40-9. doi: 10.1111/nyas.12971. Epub 2015 Dec 8.

DOI:10.1111/nyas.12971
PMID:26645136
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6472264/
Abstract

Interventions that improve health are often associated with longevity. Reduced growth hormone signaling has been shown to increase life span in mice by over 50%. Similarly, reductions in dietary intake of methionine, in rats and mice, result in life-span extension. Many factors affect metabolic health, mitochondrial function, and resistance to stressors, each of which influence aging and life span. This paper presents a comparison of these two interventions, as well as the results of a study combining these interventions, to understand potential mechanisms underlying their effectiveness in enhancing healthy aging.

摘要

改善健康的干预措施通常与长寿相关。已证明减少生长激素信号可使小鼠寿命延长50%以上。同样，在大鼠和小鼠中减少蛋氨酸的饮食摄入量会导致寿命延长。许多因素会影响代谢健康、线粒体功能和对应激源的抵抗力，每一个因素都会影响衰老和寿命。本文对这两种干预措施以及将这两种干预措施结合起来的一项研究结果进行了比较，以了解它们在促进健康衰老方面有效性的潜在机制。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/6472264/8d15e2427652/nihms-1018532-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/6472264/8f306781f849/nihms-1018532-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/6472264/8d15e2427652/nihms-1018532-f0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/6472264/8f306781f849/nihms-1018532-f0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7913/6472264/8d15e2427652/nihms-1018532-f0002.jpg

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Biol Pharm Bull. 2015;38(7):971-4. doi: 10.1248/bpb.b15-00244.
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Cysteine dietary supplementation reverses the decrease in mitochondrial ROS production at complex I induced by methionine restriction.补充膳食半胱氨酸可逆转蛋氨酸限制诱导的复合体I处线粒体活性氧生成的减少。
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Dietary L-methionine restriction decreases oxidative stress in porcine liver mitochondria.
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Metabolism and the Epigenome: A Dynamic Relationship.代谢与表观基因组：动态关系。
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Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism.长寿生长激素释放激素敲除小鼠的转录组和代谢组学分析：线粒体功能和氨基酸代谢改变的证据。
Aging (Albany NY). 2020 Feb 23;12(4):3473-3485. doi: 10.18632/aging.102822.
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