Tropskaya N S, Kislyakova E A, Popova T S
N. V. Sklifosovsky Research Institute of Emergency Medicine, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med. 2015 Dec;160(2):219-22. doi: 10.1007/s10517-015-3133-0. Epub 2015 Dec 8.
The effect of enteral administration of tributyrin on electrical activity in the upper segments of the small intestine was examined in rats on the model of postoperative ileus. This postoperative state is characterized with pronounced and long-term disturbances in generation of migrating myoelectric complex of the small intestine. The enteral administration of tributyrin in the early postoperative period aimed to suppress the non-adrenergic non-cholinergic influences and activation of the cholinergic anti-inflammatory pathways is an effective procedure to normalize the migrating myoelectric complex and therefore the coordinated propulsive peristalsis in the small intestine.
在大鼠术后肠梗阻模型中，研究了肠内给予三丁酸甘油酯对小肠上段电活动的影响。这种术后状态的特征是小肠移行性肌电复合波的产生出现明显且长期的紊乱。术后早期肠内给予三丁酸甘油酯旨在抑制非肾上腺素能非胆碱能影响并激活胆碱能抗炎途径，这是使小肠移行性肌电复合波正常化并进而使小肠协调推进性蠕动正常化的有效方法。
