Tropskaya N S, Kislyakova E A, Popova T S
N. V. Sklifosovsky Research Institute of Emergency Medicine, Moscow Department of Health, Moscow, Russia.
Bull Exp Biol Med. 2017 Oct;163(6):796-800. doi: 10.1007/s10517-017-3906-8. Epub 2017 Oct 24.
The study examined implication of tributyrin, a metabolic precursor in small intestinal microflora, in stimulation of electrical activity of duodenum and jejunum. Enteral administration of tributyrin enhanced electrical activity of both examined structures in small intestine with elimination of the rest periods. The stimulatory effect was manifested in a prolongation of the periods of irregular activity. The up-regulating effects of tributyrin on electrical activity in upper segments of small intestine are mediated via the cholecystokinin receptors being also associated with activation of cholinergic and blockade of nitrinergic signal transduction pathways.
该研究检测了小肠微生物群的代谢前体三丁酸甘油酯对十二指肠和空肠电活动的影响。经肠给予三丁酸甘油酯可增强小肠中这两个被检测结构的电活动，并消除静息期。刺激作用表现为不规则活动期的延长。三丁酸甘油酯对小肠上段电活动的上调作用是通过胆囊收缩素受体介导的，这也与胆碱能的激活和一氧化氮能信号转导途径的阻断有关。
