McCluggage W Glenn
Department of Pathology, Belfast Health and Social Care Trust, Belfast, Northern Ireland, UK.
Adv Anat Pathol. 2016 Jan;23(1):58-69. doi: 10.1097/PAP.0000000000000095.
Most adenocarcinomas in the lower female genital tract (cervix, vagina, vulva) arise in the cervix and are associated with high-risk human papillomavirus (HPV) infection. However, there is an emerging spectrum of non-HPV-related cervical adenocarcinomas, the most common of which is so-called gastric type. In this review, the concept of gastric-type cervical adenocarcinomas and their possible precursor lesions is covered, the precursor lesions still being poorly understood. Other non-HPV-related cervical adenocarcinomas are also discussed, including new information regarding molecular events in mesonephric adenocarcinoma. A variety of primary vaginal adenocarcinomas, including clear cell, endometrioid, intestinal and gastric types are also discussed. The spectrum of benign and malignant glandular lesions involving the lower female genital tract and probably derived from misplaced Skene's (periurethral) glands is also covered.
大多数女性下生殖道（子宫颈、阴道、外阴）腺癌起源于子宫颈，且与高危型人乳头瘤病毒（HPV）感染相关。然而，出现了一系列与HPV无关的子宫颈腺癌，其中最常见的是所谓的胃型。在本综述中，涵盖了胃型子宫颈腺癌及其可能的前驱病变的概念，而前驱病变仍了解甚少。还讨论了其他与HPV无关的子宫颈腺癌，包括关于中肾腺癌分子事件的新信息。还讨论了多种原发性阴道腺癌，包括透明细胞型、子宫内膜样型、肠型和胃型。还涵盖了可能起源于异位的斯基恩氏（尿道周围）腺的累及女性下生殖道的良性和恶性腺性病变谱。
