Pascoe E, Falvey T, Jiwane A, Henry G, Krishnan U
Sydney Children's Hospital Randwick (SCH), Sydney, Australia.
University of New South Wales (UNSW), Sydney, Australia.
Pediatr Surg Int. 2016 Apr;32(4):353-61. doi: 10.1007/s00383-015-3843-4. Epub 2015 Dec 8.
Outcomes of fundoplication in children.
In this monocentric retrospective study, chart review was performed on children who underwent fundoplication between 2006 and 2013. Outcomes were defined as the need for redo fundoplication and recommencement of anti-reflux medication (ARM) at 6-month follow-up.
119 patients underwent fundoplication with a mean age of 4.76 years and 55.5% of these were male. At 6-month follow-up, 21 (17.6%) required redo fundoplication and 64 (53.8%) were recommenced on ARM. Post-operative complications occurred in 50 (42.2%) of children; 30% of those with complications had surgery at less than 1 year of age, and 36% had an associated comorbid condition. Neither being under the age of one nor associated comorbidity was significantly associated with a poor outcome. Concurrent gastrostomy was associated with a higher risk of being back on ARM at 6-month follow-up (p = 0.003). Neither gastrointestinal or respiratory symptoms pre-surgery nor abnormal pre-operative investigations including pH monitoring and endoscopy were predictive of poor outcome post-fundoplication.
Although fundoplication has a role in the treatment of severe GORD in children, the majority of children in this study needed to restart their anti-reflux medications within 6 months of surgery.
儿童胃底折叠术的治疗结果。
在这项单中心回顾性研究中,对2006年至2013年间接受胃底折叠术的儿童进行了病历审查。结局定义为在6个月随访时是否需要再次进行胃底折叠术以及重新开始使用抗反流药物(ARM)。
119例患者接受了胃底折叠术,平均年龄为4.76岁,其中55.5%为男性。在6个月随访时,21例(17.6%)需要再次进行胃底折叠术,64例(53.8%)重新开始使用ARM。50例(42.2%)儿童发生了术后并发症;30%发生并发症的儿童在1岁之前接受了手术,36%伴有合并症。年龄小于1岁和合并症均与不良结局无显著相关性。同期胃造口术与6个月随访时重新使用ARM的较高风险相关(p = 0.003)。术前的胃肠道或呼吸道症状以及包括pH监测和内镜检查在内的术前异常检查均不能预测胃底折叠术后的不良结局。
尽管胃底折叠术在儿童重度胃食管反流病的治疗中具有一定作用,但本研究中的大多数儿童在手术后6个月内需要重新开始使用抗反流药物。