衰老的代谢调控。

The metabolic regulation of aging.

机构信息

Center for Molecular Medicine, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.

出版信息

Nat Med. 2015 Dec;21(12):1416-23. doi: 10.1038/nm.3998.

DOI:10.1038/nm.3998

PMID:26646498

Abstract

Here we review the environmental and genetic manipulations that link cellular and organismal metabolism to aging. In particular, we explore how nutrients are sensed and how various intracellular energy nodes seem to coordinate distinct metabolic alterations linked to extended longevity. In addition, the role of mitochondria as both a metabolic and signaling organelle is discussed. Finally, we review a host of new targeted pharmacological approaches that attempt to exploit the connection between aging and metabolism to treat a wide range of age-related diseases. Together, these insights are beginning to reveal answers to century-old mysteries and are providing a future road map for the rational extension of lifespan.

摘要

在这里，我们回顾了将细胞和机体代谢与衰老联系起来的环境和遗传操作。特别是，我们探讨了营养物质是如何被感知的，以及各种细胞内能量节点如何似乎协调与延长寿命相关的不同代谢变化。此外，还讨论了线粒体作为代谢和信号细胞器的作用。最后，我们回顾了一系列新的靶向药理方法，这些方法试图利用衰老和代谢之间的联系来治疗广泛的与年龄相关的疾病。总之，这些见解开始揭示了百年谜团的答案，并为合理延长寿命提供了未来的路线图。