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含银纳米颗粒的类金刚石碳涂层钛合金的抗菌功效。

Antibacterial efficacy of titanium-containing alloy with silver-nanoparticles enriched diamond-like carbon coatings.

作者信息

Harrasser Norbert, Jüssen Sebastian, Banke Ingo J, Kmeth Ralf, von Eisenhart-Rothe Ruediger, Stritzker Bernd, Gollwitzer Hans, Burgkart Rainer

机构信息

Clinic of Orthopedics and Sports Orthopedics, Klinikum rechts der Isar, Technical University of Munich, Ismaninger Str. 22, 81675, Munich, Germany.

Experimental Physics IV, Institut für Physik, Augsburg University, Universitätsstr. 1, 86135, Augsburg, Germany.

出版信息

AMB Express. 2015 Dec;5(1):77. doi: 10.1186/s13568-015-0162-z. Epub 2015 Dec 9.

DOI:10.1186/s13568-015-0162-z
PMID:26646789
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4673079/
Abstract

Silver ions (Ag(+)) have strong bactericidal effects and Ag-coated medical devices proved their effectiveness in reducing infections in revision total joint arthroplasty. We quantitatively determined the antimicrobial potency of different surface treatments on a titanium alloy (Ti), which had been conversed to diamond-like carbon (DLC-Ti) and doped with high (Ag:PVP = 1:2) and low (Ag:PVP = 1:10 and 1:20) concentrations of Ag (Ag-DLC-Ti) with a modified technique of ion implantation. Bacterial adhesion and planktonic growth of clinically relevant bacterial strains (Staphylococcus epidermidis, Staphylococcus aureus, and Pseudomonas aeruginosa) on Ag-DLC-Ti were compared to untreated Ti by quantification of colony forming units on the adherent surface and in the growth medium as well as semiquantitatively by determining the grade of biofilm formation by scanning electron microscopy. (1) A significant (p < 0.05) antimicrobial effect could be found for all Ag-DLC-Ti samples (reduced growth by 5.6-2.5 logarithmic levels). (2) The antimicrobial effect was depending on the tested bacterial strain (most for P. aeruginosa, least for S. aureus). (3) Antimicrobial potency was positively correlated with Ag concentrations. (4) Biofilm formation was decreased by Ag-DLC-Ti surfaces. This study revealed potent antibacterial effects of Ag-DLC-Ti. This may serve as a promising novel approach to close the gap in antimicrobial protection of musculoskeletal implants.

摘要

银离子（Ag(+)）具有很强的杀菌作用，并且涂银的医疗器械已证明其在减少翻修全关节置换术中感染方面的有效性。我们定量测定了不同表面处理对一种钛合金（Ti）的抗菌效力，该钛合金已转化为类金刚石碳（DLC-Ti），并通过改进的离子注入技术掺杂了高浓度（Ag:PVP = 1:2）和低浓度（Ag:PVP = 1:10和1:20）的银（Ag-DLC-Ti）。通过对粘附表面和生长培养基上的菌落形成单位进行定量，以及通过扫描电子显微镜确定生物膜形成等级进行半定量，将临床相关细菌菌株（表皮葡萄球菌、金黄色葡萄球菌和铜绿假单胞菌）在Ag-DLC-Ti上的细菌粘附和浮游生长与未处理的Ti进行比较。（1）所有Ag-DLC-Ti样品均具有显著（p < 0.05）的抗菌效果（生长减少5.6 - 2.5个对数水平）。（2）抗菌效果取决于所测试的细菌菌株（对铜绿假单胞菌影响最大，对金黄色葡萄球菌影响最小）。（3）抗菌效力与银浓度呈正相关。（4）Ag-DLC-Ti表面减少了生物膜的形成。本研究揭示了Ag-DLC-Ti具有强大的抗菌作用。这可能是一种有前景的新方法，以弥补肌肉骨骼植入物抗菌保护方面的差距。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/ff38ea47a716/13568_2015_162_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/eb61cf15bb49/13568_2015_162_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/abe8ca3aae4e/13568_2015_162_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/18e9622d1d5d/13568_2015_162_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/c20ff1afdc8c/13568_2015_162_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/d97be3204e48/13568_2015_162_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/ff38ea47a716/13568_2015_162_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/eb61cf15bb49/13568_2015_162_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/abe8ca3aae4e/13568_2015_162_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/18e9622d1d5d/13568_2015_162_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/c20ff1afdc8c/13568_2015_162_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/d97be3204e48/13568_2015_162_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c133/4673079/ff38ea47a716/13568_2015_162_Fig6_HTML.jpg

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本文引用的文献

[1]
Antibacterial efficacy of ultrahigh molecular weight polyethylene with silver containing diamond-like surface layers.

AMB Express. 2015-9-21

[2]
On the long term antibacterial features of silver-doped diamondlike carbon coatings deposited via a hybrid plasma process.

Biointerphases. 2014-6

[3]
Multi-layer haemocompatible diamond-like carbon coatings obtained by combined radio frequency plasma enhanced chemical vapor deposition and magnetron sputtering.

J Mater Sci Mater Med. 2013-12

[4]
Citrate-capped silver nanoparticles showing good bactericidal effect against both planktonic and sessile bacteria and a low cytotoxicity to osteoblastic cells.

ACS Appl Mater Interfaces. 2013-4-12

[5]
Influence of silver incorporation on the structural and electrical properties of diamond-like carbon thin films.

ACS Appl Mater Interfaces. 2013-4-1

[6]
The antimicrobial and osteoinductive properties of silver nanoparticle/poly (DL-lactic-co-glycolic acid)-coated stainless steel.

Biomaterials. 2012-9-7

[7]
Antibacterial activity of glutathione-coated silver nanoparticles against Gram positive and Gram negative bacteria.

Langmuir. 2012-5-15

[8]
Pathogenesis and treatment concepts of orthopaedic biofilm infections.

FEMS Immunol Med Microbiol. 2012-7

[9]
Decreasing bacterial colonization of external fixation pins through nitric oxide release coatings.

J Orthop Trauma. 2011-7

[10]
In vitro adhesion of staphylococci to diamond-like carbon polymer hybrids under dynamic flow conditions.

J Mater Sci Mater Med. 2011-1-18

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