Center for Innovative Clinical Medicine, Okayama University Hospital, Okayama University, Okayama 700-8558, Japan.
Institute of Frontier Science and Technology, Okayama University of Science, Okayama 700-0005, Japan.
Int J Mol Sci. 2024 Aug 6;25(16):8593. doi: 10.3390/ijms25168593.
The medical device market is a high-growth sector expected to sustain an annual growth rate of over 5%, even in developed countries. Daily, numerous patients have medical devices implanted or inserted within their bodies. While medical devices have significantly improved patient outcomes, as foreign objects, their wider use can lead to an increase in device-related infections, thereby imposing a burden on healthcare systems. Multiple materials with significant societal impact have evolved over time: the 19th century was the age of iron, the 20th century was dominated by silicon, and the 21st century is often referred to as the era of carbon. In particular, the development of nanocarbon materials and their potential applications in medicine are being explored, although the scope of these applications remains limited. Technological innovations in carbon materials are remarkable, and their application in medicine is expected to advance greatly. For example, diamond-like carbon (DLC) has garnered considerable attention for the development of antimicrobial surfaces. Both DLC itself and its derivatives have been reported to exhibit anti-microbial properties. This review discusses the current state of DLC-based antimicrobial surface development.
医疗器械市场是一个高增长领域，预计即使在发达国家，其年增长率也将超过 5%。每天都有大量患者的体内被植入或插入医疗器械。虽然医疗器械极大地改善了患者的预后，但作为异物，它们的广泛使用会导致与器械相关的感染增加，从而给医疗保健系统带来负担。随着时间的推移，出现了多种具有重大社会影响的材料：19 世纪是铁的时代，20 世纪由硅主导，21 世纪通常被称为碳时代。特别是，纳米碳材料的发展及其在医学中的潜在应用正在被探索，尽管这些应用的范围仍然有限。碳材料的技术创新引人注目，预计其在医学中的应用将取得重大进展。例如，类金刚石碳（DLC）因其开发抗菌表面而受到广泛关注。DLC 本身及其衍生物已被报道具有抗微生物特性。这篇综述讨论了基于 DLC 的抗菌表面开发的现状。
