Academy of Biology and Biotechnology, Southern Federal University, Rostov-on-Don, Russia.
Center for Agrobiotechnology, Don State Technical University, Rostov-on-Don, Russia.
Probiotics Antimicrob Proteins. 2021 Aug;13(4):926-948. doi: 10.1007/s12602-021-09776-6. Epub 2021 Mar 18.
Pathogenic Candida and infections caused by those species are now considered as a serious threat to public health. The treatment of candidiasis is significantly complicated by the increasing resistance of pathogenic strains to current treatments and the stagnant development of new antimycotic drugs. Many species, such as Candida auris, have a wide range of resistance mechanisms. Among the currently used synthetic and semi-synthetic antifungal drugs, the most effective are azoles, echinocandins, polyenes, nucleotide analogs, and their combinations. However, the use of probiotic microorganisms and/or the compounds they produce is quite promising, although underestimated by modern pharmacology, to control the spread of pathogenic Candida species.
致病性念珠菌及其引发的感染，如今被视为严重的公共健康威胁。当前治疗方法的抗药性不断增强，新型抗真菌药物研发停滞不前，这使得念珠菌病的治疗变得更加复杂。许多物种，如耳念珠菌，具有广泛的耐药机制。在目前使用的合成和半合成抗真菌药物中，最有效的是唑类、棘白菌素类、多烯类、核苷酸类似物及其组合。然而，尽管现代药理学对此有所低估，使用益生菌微生物及其产生的化合物来控制致病性念珠菌的传播还是颇具前景的。
