Piątczak Ewelina, Kuźma Łukasz, Porada Weronika, Olas Beata, Wysokińska Halina
Acta Pol Pharm. 2015 Jul-Aug;72(4):777-83.
Compounds with antioxidant activity may protect different elements of blood from damaging effects of oxidative stress. The present in vitro study was designed to examine the antioxidant activity of methanolic extracts from leaves and roots of R. glutinosa plants against damages induced by oxidative stress. Oxidative stress was stimulated in human plasma and human blood platelet samples by the strong biological oxidant--hydrogen peroxide (H2O2) or H2O2/Fe (the donor of hydroxyl radicals). In experimental trials, the level of biomarker of lipid peroxidation--TBARS was significantly decreased by the action of methanolic extracts from R. glutinosa leaves. Therefore, it seems that the methanolic extract from leaves of the plants may be a new source of bioactive antioxidant natural compounds. It may be also an active pharmacological agent or a food supplement for healthy subjects and for people with different diseases (cardiovascular diseases and cancer) induced by oxidative stress.
具有抗氧化活性的化合物可能保护血液中的不同成分免受氧化应激的破坏作用。本体外研究旨在检测地黄植株叶和根的甲醇提取物对氧化应激诱导损伤的抗氧化活性。通过强生物氧化剂——过氧化氢（H2O2）或H2O2/铁（羟基自由基供体）在人血浆和人血小板样本中诱导氧化应激。在实验中，地黄叶甲醇提取物的作用显著降低了脂质过氧化生物标志物——硫代巴比妥酸反应物（TBARS）的水平。因此，该植物叶的甲醇提取物似乎可能是生物活性抗氧化天然化合物的新来源。它也可能是一种活性药物制剂或健康受试者以及患有由氧化应激引起的不同疾病（心血管疾病和癌症）的人群的食品补充剂。
