癌症的口服靶向治疗
Oral targeted therapy for cancer.
作者信息
Carrington Christine
机构信息
Assistant director of pharmacy, Senior consultant pharmacist - cancer services, Princess Alexandra Hospital, Brisbane.
出版信息
Aust Prescr. 2015 Oct;38(5):171-6. doi: 10.18773/austprescr.2015.060. Epub 2015 Oct 1.
Abstract
Oral targeted therapies are increasingly being used to treat cancer. They work by interfering with specific molecules or pathways involved in tumour growth. It is essential that health professionals managing patients taking these drugs have appropriate training and skills. They should be aware of potential adverse effects and drug interactions, and be able to manage toxicities when they occur. Despite the selectivity of these targeted therapies, they still have serious adverse effects including skin reactions, diarrhoea and altered organ function.
摘要
口服靶向疗法越来越多地用于治疗癌症。它们通过干扰肿瘤生长所涉及的特定分子或途径发挥作用。管理服用这些药物患者的医护人员接受适当的培训并具备相关技能至关重要。他们应了解潜在的不良反应和药物相互作用，并能够在出现毒性反应时进行处理。尽管这些靶向疗法具有选择性，但它们仍然会产生严重的不良反应，包括皮肤反应、腹泻和器官功能改变。
相似文献
1
Oral targeted therapy for cancer.癌症的口服靶向治疗
Aust Prescr. 2015 Oct;38(5):171-6. doi: 10.18773/austprescr.2015.060. Epub 2015 Oct 1.
2
Cutaneous reactions to chemotherapeutic drugs and targeted therapy for cancer: Part II. Targeted therapy.癌症化疗药物和靶向治疗的皮肤反应：第二部分。靶向治疗。
J Am Acad Dermatol. 2014 Aug;71(2):217.e1-217.e11; quiz 227-8. doi: 10.1016/j.jaad.2014.04.013.
3
Oral adverse events associated with targeted cancer therapies.与靶向癌症治疗相关的口腔不良事件。
Gen Dent. 2018 Sep-Oct;66(5):26-31.
4
Management of pulmonary toxicity associated with targeted anticancer therapies.与靶向抗癌治疗相关的肺部毒性的管理。
Expert Opin Drug Metab Toxicol. 2015;11(11):1695-707. doi: 10.1517/17425255.2015.1080687. Epub 2015 Aug 19.
5
Targeted tumour therapy induced papulopustular rash and other dermatologic side effects: a retrospective study.靶向肿瘤治疗引起的丘疹脓疱性皮疹及其他皮肤副作用：一项回顾性研究
Cutan Ocul Toxicol. 2019 Sep;38(3):261-266. doi: 10.1080/15569527.2019.1594874. Epub 2019 May 7.
6
Safety Profiles and Pharmacovigilance Considerations for Recently Patented Anticancer Drugs: Cutaneous Melanoma.最近获得专利的抗癌药物的安全性概况和药物警戒学考虑因素：皮肤黑色素瘤。
Recent Pat Anticancer Drug Discov. 2019;14(3):203-225. doi: 10.2174/1574892814666190726130351.
7
Molecular mechanisms for vascular complications of targeted cancer therapies.靶向癌症治疗血管并发症的分子机制。
Clin Sci (Lond). 2016 Oct 1;130(20):1763-79. doi: 10.1042/CS20160246.
8
Strategies for assessing and managing the adverse events of sorafenib and other targeted therapies in the treatment of renal cell and hepatocellular carcinoma: recommendations from a European nursing task group.评估和管理索拉非尼和其他靶向治疗药物治疗肾细胞癌和肝细胞癌的不良反应的策略：来自欧洲护理工作组的建议。
Eur J Oncol Nurs. 2012 Apr;16(2):172-84. doi: 10.1016/j.ejon.2011.05.001. Epub 2011 Jun 8.
9
Cutaneous adverse effects of targeted therapies: Part I: Inhibitors of the cellular membrane.靶向治疗的皮肤不良反应：第一部分：细胞膜抑制剂。
J Am Acad Dermatol. 2015 Feb;72(2):203-18; quiz 219-20. doi: 10.1016/j.jaad.2014.07.032.
10
Managing Cutaneous Side Effects From Targeted Molecular Inhibitors for Melanoma and Nonmelanoma Skin Cancer.应对黑色素瘤和非黑色素瘤皮肤癌靶向分子抑制剂引起的皮肤副作用
Dermatol Surg. 2016 Jan;42 Suppl 1:S40-8. doi: 10.1097/DSS.0000000000000519.
引用本文的文献
1
The effect of healthcare professional-implemented interventions on adherence to oral targeted therapy in patients with cancer: a systematic review and meta-analysis.医疗保健专业人员实施的干预措施对癌症患者口服靶向治疗依从性的影响：一项系统评价和荟萃分析。
Support Care Cancer. 2025 Jan 17;33(2):110. doi: 10.1007/s00520-024-09136-4.
2
Targeting of promising transmembrane proteins for diagnosis and treatment of pancreatic ductal adenocarcinoma.针对胰腺导管腺癌的有前途的跨膜蛋白的诊断和治疗。
Theranostics. 2021 Aug 25;11(18):9022-9037. doi: 10.7150/thno.60350. eCollection 2021.
3
Chronic leukaemias in the community.社区中的慢性白血病。
Aust Prescr. 2020 Aug;43(4):126-130. doi: 10.18773/austprescr.2020.034. Epub 2020 Aug 3.
4
Developing an Improved Statistical Approach for Survival Estimation in Bone Metastases Management: The Bone Metastases Ensemble Trees for Survival (BMETS) Model.开发一种改进的生存估计统计方法在骨转移管理：骨转移集成树生存模型 (BMETS)。
Int J Radiat Oncol Biol Phys. 2020 Nov 1;108(3):554-563. doi: 10.1016/j.ijrobp.2020.05.023. Epub 2020 May 22.
5
Reviewing the role of healthy volunteer studies in drug development.审查健康志愿者研究在药物开发中的作用。
J Transl Med. 2018 Dec 4;16(1):336. doi: 10.1186/s12967-018-1710-5.
本文引用的文献
1
Medical management of malignant melanoma.恶性黑色素瘤的医学管理
Aust Prescr. 2015 Jun;38(3):74-8. doi: 10.18773/austprescr.2015.028. Epub 2015 Mar 11.
2
Venous thromboembolism prophylaxis and treatment in patients with cancer: american society of clinical oncology clinical practice guideline update 2014.癌症患者的静脉血栓栓塞预防与治疗：美国临床肿瘤学会2014年临床实践指南更新
J Clin Oncol. 2015 Feb 20;33(6):654-6. doi: 10.1200/JCO.2014.59.7351. Epub 2015 Jan 20.
3
Drug interactions between tyrosine-kinase inhibitors and acid suppressive agents: more than meets the eye.酪氨酸激酶抑制剂与抑酸剂之间的药物相互作用：比表面现象更复杂。
Lancet Oncol. 2014 Oct;15(11):e469-70. doi: 10.1016/S1470-2045(14)70458-9.
4
Combined BRAF and MEK inhibition versus BRAF inhibition alone in melanoma.BRAF 和 MEK 联合抑制与单独 BRAF 抑制治疗黑色素瘤。
N Engl J Med. 2014 Nov 13;371(20):1877-88. doi: 10.1056/NEJMoa1406037. Epub 2014 Sep 29.
5
Guidance on the management of diarrhoea during cancer chemotherapy.癌症化疗期间腹泻管理指南。
Lancet Oncol. 2014 Sep;15(10):e447-60. doi: 10.1016/S1470-2045(14)70006-3.
6
Current treatment for multiple myeloma.多发性骨髓瘤的当前治疗方法。
N Engl J Med. 2014 Sep 4;371(10):961-2. doi: 10.1056/NEJMe1407442.
7
Metabolism-related pharmacokinetic drug-drug interactions with tyrosine kinase inhibitors: current understanding, challenges and recommendations.酪氨酸激酶抑制剂与代谢相关的药代动力学药物相互作用：当前认识、挑战与建议
Br J Clin Pharmacol. 2015 Feb;79(2):241-53. doi: 10.1111/bcp.12496.
8
Drug-drug interactions with tyrosine-kinase inhibitors: a clinical perspective.药物-药物相互作用与酪氨酸激酶抑制剂：临床视角。
Lancet Oncol. 2014 Jul;15(8):e315-26. doi: 10.1016/S1470-2045(13)70579-5.
9
Retinoic acid and arsenic trioxide for acute promyelocytic leukemia.全反式维甲酸和三氧化二砷联合治疗急性早幼粒细胞白血病。
N Engl J Med. 2013 Jul 11;369(2):111-21. doi: 10.1056/NEJMoa1300874.
10
Pazopanib: in advanced soft tissue sarcoma.帕唑帕尼：治疗晚期软组织肉瘤。
Drugs. 2012 Nov 12;72(16):2129-40. doi: 10.2165/11209950-000000000-00000.
Zotero 插件