Lesmana Cosmas Rinaldi A, Pakasi Levina S, Inggriani Sri, Aidawati Maria L, Lesmana Laurentius A
Digestive Disease & GI Oncology Center, Medistra Hospital, Jakarta, Indonesia.
Department of Internal Medicine, Hepatobiliary Division, Cipto Mangunkusumo Hospital, University of Indonesia, Jakarta, Indonesia.
BMC Gastroenterol. 2015 Dec 12;15:174. doi: 10.1186/s12876-015-0404-1.
The clinical significance of non-alcoholic fatty pancreatic disease (NAFPD) or fatty pancreas is largely unknown. It is often an incidental finding on abdominal ultrasound, which is not explored further, especially its association with metabolic condition and the risk of pancreatic malignancy. The aim of this study is to evaluate the presence of NAFPD and its associated risk factors among adult medical check-up patients.
A large cross-sectional study was done among adult medical check-up patients underwent abdominal ultrasound between January and December 2013 in Medistra Hospital, Jakarta. Data was obtained from the patients' medical record and include demographic data, blood pressures, fasting blood glucose level, and lipid profile. The presence of fatty pancreas was diagnosed by ultrasound. Bivariate and multivariate analyses were done to find associated risk factors for NAFPD. Statistical analysis was done using SPSS version 17.
A total of 1054 cases were included in this study; pancreas cannot be visualized in 153 cases and were excluded from the analysis. Fatty pancreas was present in 315 (35.0%) patients. Bivariate analyses found associations among fatty pancreas and several risk factors such as gender, age, systolic and diastolic blood pressures, body mass index (BMI), fasting plasma glucose (FPG), triglycerides (TG) and cholesterol levels.
Fatty pancreas is a common finding during medical check-up with a prevalence of 35%. Fatty pancreas has significant association with metabolic factors and it might have an important role in risk of malignancy.
非酒精性脂肪性胰腺疾病（NAFPD）或胰腺脂肪变性的临床意义在很大程度上尚不清楚。它常常是腹部超声检查时的偶然发现，并未进一步探究，尤其是其与代谢状况及胰腺恶性肿瘤风险的关联。本研究的目的是评估成年体检患者中NAFPD的存在情况及其相关危险因素。
2013年1月至12月期间，在雅加达Medistra医院对接受腹部超声检查的成年体检患者进行了一项大型横断面研究。数据取自患者病历，包括人口统计学数据、血压、空腹血糖水平和血脂谱。通过超声诊断胰腺脂肪变性。进行双变量和多变量分析以找出NAFPD的相关危险因素。使用SPSS 17版进行统计分析。
本研究共纳入1054例病例；153例病例胰腺无法可视化，被排除在分析之外。315例（35.0%）患者存在胰腺脂肪变性。双变量分析发现胰腺脂肪变性与多个危险因素相关，如性别、年龄、收缩压和舒张压、体重指数（BMI）、空腹血糖（FPG）、甘油三酯（TG）和胆固醇水平。
胰腺脂肪变性在体检中是常见发现，患病率为35%。胰腺脂肪变性与代谢因素有显著关联，可能在恶性肿瘤风险中起重要作用。
