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黏膜IgG水平比血浆IgG水平与呼吸道合胞病毒载量及炎症的相关性更好。

Mucosal IgG Levels Correlate Better with Respiratory Syncytial Virus Load and Inflammation than Plasma IgG Levels.

作者信息

Vissers Marloes, Ahout Inge M L, de Jonge Marien I, Ferwerda Gerben

机构信息

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.

Laboratory of Pediatric Infectious Diseases, Department of Pediatrics, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands

出版信息

Clin Vaccine Immunol. 2015 Dec 9;23(3):243-5. doi: 10.1128/CVI.00590-15.

DOI:10.1128/CVI.00590-15
PMID:26656116
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4783421/
Abstract

Maternal vaccination is currently considered a strategy against respiratory syncytial virus (RSV) infections. In RSV-infected infants, high mucosal IgG levels correlated better with reduced RSV load and lower mucosal CXCL10 levels than plasma IgG levels. For future vaccination strategies against RSV, more focus should be on the mucosal humoral immune response.

摘要

目前，母体疫苗接种被认为是一种预防呼吸道合胞病毒（RSV）感染的策略。在感染RSV的婴儿中，与血浆IgG水平相比，较高的黏膜IgG水平与降低RSV载量及较低的黏膜CXCL10水平的相关性更好。对于未来预防RSV的疫苗接种策略，应更多地关注黏膜体液免疫反应。

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