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植物对心血管疾病的影响。

Botanical influences on cardiovascular disease.

作者信息

Miller A L

机构信息

Alternative Medicine Review. P.O. Box 25, Dover, ID 83825, USA.

出版信息

Altern Med Rev. 1998 Dec;3(6):422-31.

PMID:9855567
Abstract

Several botanicals, including Crataegus oxycantha, Terminalia arjuna, Inula racemosa, and Astragalus membranaceus, have been found to have therapeutic benefit for the treatment of cardiovascular disease. Crataegus oxycantha has been used traditionally as a cardiac tonic and current uses include treatment for angina, hypertension, arrhythmias, and congestive heart failure. Animal studies have also indicated that Crataegus extracts may also have potential use as anti-ischemic and lipid-lowering agents. The bark of the Terminalia arjuna tree has a long history of use as a cardiac tonic as well, and has been indicated in the treatment of coronary artery disease, heart failure, hypercholesterolemia and for relief of anginal pain. Additionally, it has been found to have antibacterial and antimutagenic properties. Inula racemosa, also known as Pushkarmoola, is another traditional Ayurvedic botanical that has potential cardioprotective benefit. In human trials, a combination of Inula racemosa and Commiphora mukul was shown to be superior to nitroglycerin in reducing the chest pain and dyspnea associated with angina. Astragalus membranaceus, a Chinese herb, is often used as a "Qi tonifier" and has been studied for its therapeutic benefit in treatment of ischemic heart disease, myocardial infarction, heart failure, and relief of anginal pain. Clinical studies have indicated that its in vitro antioxidant activity is the mechanism by which it affords its cardioprotective benefit.

摘要

包括山楂、印度楝、总状土木香和黄芪在内的几种植物药已被发现对心血管疾病的治疗具有治疗益处。山楂传统上被用作心脏滋补剂,目前的用途包括治疗心绞痛、高血压、心律失常和充血性心力衰竭。动物研究还表明,山楂提取物也可能有作为抗缺血和降脂药物的潜在用途。印度楝树的树皮也长期被用作心脏滋补剂,并已被用于治疗冠状动脉疾病、心力衰竭、高胆固醇血症和缓解心绞痛。此外,还发现它具有抗菌和抗诱变特性。总状土木香,也被称为普什卡尔穆拉,是另一种具有潜在心脏保护益处的传统阿育吠陀植物药。在人体试验中,总状土木香和没药的组合在减轻与心绞痛相关的胸痛和呼吸困难方面被证明优于硝酸甘油。黄芪是一种中国草药,常被用作“补气药”,并已对其在治疗缺血性心脏病、心肌梗死、心力衰竭和缓解心绞痛方面的治疗益处进行了研究。临床研究表明,其体外抗氧化活性是其提供心脏保护益处的机制。

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