Li Dun-Hui, He Ya-Chao, Quinn Thomas J, Liu Jun
Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China.
Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan, 48073, United States of America.
PLoS One. 2015 Dec 11;10(12):e0144755. doi: 10.1371/journal.pone.0144755. eCollection 2015.
Insulin-like growth factor-1 (IGF-1) is reported to be neuroprotective in the setting of Parkinson's disease (PD), and there is increasing interest in the possible association of serum IGF-1 levels with PD patients, but with conflicting results. Therefore, we conducted a meta-analysis to evaluate the association of serum IGF-1 levels in de novo, drug naïve PD patients compared with healthy controls.
Pubmed, ISI Web of Science, OVID, EMBASE, and Cochrane library databases from 1966 to October 2014 were utilized to identify candidate studies using Medical Subjective Headings without language restriction. A random-effects model was chosen, with subgroup analysis and sensitivity analysis conducted to reveal underlying heterogeneity among the included studies.
In this meta-analysis, we found that PD patients had higher serum IGF-1 levels compared with healthy controls (summary mean difference [MD] = 17.75, 95%CI = 6.01, 29.48). Subgroup analysis demonstrated that the source of heterogeneity was population differences within the total group. Sensitivity analysis showed that the combined MD was consistent at any time omitting any one study.
The results of this meta-analysis demonstrate that serum IGF-1 levels were significantly higher in de novo, drug-naïve PD patients compared with healthy controls. Nevertheless, additional endeavors are required to further explore the association between serum IGF-1 levels and diagnosis, prognosis and early therapy for PD.
据报道，胰岛素样生长因子-1（IGF-1）在帕金森病（PD）中具有神经保护作用，并且人们越来越关注血清IGF-1水平与PD患者之间可能存在的关联，但结果相互矛盾。因此，我们进行了一项荟萃分析，以评估初发、未用药的PD患者与健康对照者血清IGF-1水平的关联。
利用1966年至2014年10月的PubMed、科学引文索引（ISI）Web of Science、OVID、EMBASE和Cochrane图书馆数据库，使用医学主题词检索候选研究，无语言限制。选择随机效应模型，并进行亚组分析和敏感性分析，以揭示纳入研究之间潜在的异质性。
在这项荟萃分析中，我们发现与健康对照者相比，PD患者的血清IGF-1水平更高（汇总平均差[MD]=17.75，95%可信区间[CI]=6.01，29.48）。亚组分析表明，异质性来源是总组内的人群差异。敏感性分析表明，在任何时候省略任何一项研究，合并后的MD都是一致的。
这项荟萃分析的结果表明，与健康对照者相比，初发、未用药的PD患者的血清IGF-1水平显著更高。然而，需要进一步努力来进一步探索血清IGF-1水平与PD的诊断、预后和早期治疗之间的关联。
