有效的含氟漱口水给药方法作为漱口的替代方法。

Effective Fluoride Mouthwash Delivery Methods as an Alternative to Rinsing.

作者信息

Rattanawiboon Chayanit, Chaweewannakorn Chayanit, Saisakphong Tanyamai, Kasevayuth Kasekarn, Trairatvorakul Chutima

机构信息

Chayanit Rattanawiboon, DDS, is Research Associate; Chayanit Chaweewannakorn, DDS, is Research Associate; and Tanyamai Saisakphong, DDS, is Research Associate, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Kasekarn Kasevayuth, PhD, is Lecturer, Department of Biochemistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand. Chutima Trairatvorakul, M.S., is Associate Professor, Department of Pediatric Dentistry, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.

出版信息

Nurs Res. 2016 Jan-Feb;65(1):68-75. doi: 10.1097/NNR.0000000000000131.

DOI:10.1097/NNR.0000000000000131

PMID:26657482

Abstract

BACKGROUND

Special-needs patients with high caries risk cannot benefit from the proven caries-reducing effect of fluoride mouthrinse because of poor rinsing compliance and a lack of home-use fluoride application recommendations.

OBJECTIVES

This study aimed to evaluate whether two modified delivery methods-spray or swab application-could raise the salivary fluoride to levels similar to that of rinsing.

METHODS

Five healthy men and 16 healthy women, ages 18-22 years, participated in this crossover study. The subjects performed a standardized brushing routine twice a day with 1,000-ppm fluoride dentifrice 1 week before and during the experimental period. The three fluoride mouthwash (0.05% NaF; 226-ppm fluoride) administration methods consisted of rinsing, spray, and cotton swab application. Each application was separated by at least 1 week. Unstimulated whole saliva was sampled for 2 minutes at baseline and at 0, 5, 10, 20, 30, 60, and 120 minutes after each fluoride mouthwash application. Salivary fluoride level (ppm) was measured by a blinded investigator using an ion-specific electrode (ORION EA940). The differences in salivary fluoride concentration for each application method were analyzed by repeated measures ANOVA at a nominal significance level of .05.

RESULTS

The newly designed fluoride mouthwash delivery methods yielded a similar fluoride level in whole saliva compared to that of rinsing at all time points (p > .05). The t half-life of fluoride concentration ranged from 1.62 minutes (SD = 0.53) in the spray group to 2.08 minutes (SD = 0.87) in the cotton swab group; the values were not significantly different.

DISCUSSION

Our results indicate that the spray and cotton swab fluoride delivery methods were effective alternatives to conventional mouth rinsing. Caregivers of individuals with acute and chronic illness, including developmental disabilities affecting cognitive or physical abilities, may consider using these alternative fluoride delivery methods to help promote dental hygiene.

摘要

背景

高龋风险的特殊需求患者因漱口依从性差且缺乏家庭用氟建议，无法从已证实的含氟漱口水防龋效果中获益。

目的

本研究旨在评估两种改良给药方法——喷雾或擦拭应用——能否将唾液氟水平提高到与漱口相似的水平。

方法

5名18 - 22岁的健康男性和16名健康女性参与了这项交叉研究。在实验期之前及期间，受试者每天使用含1000 ppm氟化物的牙膏进行两次标准化刷牙。三种含氟漱口水（0.05%氟化钠；226 ppm氟化物）给药方法包括漱口、喷雾和棉签涂抹。每次应用间隔至少1周。在基线以及每次含氟漱口水应用后的0、5、10、20、30、60和120分钟采集2分钟的非刺激性全唾液。由一位不知情的研究者使用离子特异性电极（ORION EA940）测量唾液氟水平（ppm）。每种应用方法的唾液氟浓度差异通过重复测量方差分析进行分析，名义显著性水平为0.05。