Heteroreceptor Complexes and their Allosteric Receptor-Receptor Interactions as a Novel Biological Principle for Integration of Communication in the CNS: Targets for Drug Development.
作者信息
Fuxe Kjell, Borroto-Escuela Dasiel O
机构信息
Department of Neuroscience, Karolinska Institutet, Stockholm, Sweden.
出版信息
Neuropsychopharmacology. 2016 Jan;41(1):380-2. doi: 10.1038/npp.2015.244.
Abstract
摘要
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2
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3
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4
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Dopamine D2 receptors form higher order oligomers at physiological expression levels.
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