Valadkhan Saba, Valencia-Hipólito Alberto
Department of Molecular Biology and Microbiology, Case Western Reserve University School of Medicine, Cleveland, OH, 44106, USA.
Curr Top Microbiol Immunol. 2016;394:203-36. doi: 10.1007/82_2015_489.
All living organisms sense and respond to harmful changes in their intracellular and extracellular environment through complex signaling pathways that lead to changes in gene expression and cellular function in order to maintain homeostasis. Long non-coding RNAs (lncRNAs), a large and heterogeneous group of functional RNAs, play important roles in cellular response to stressful conditions. lncRNAs constitute a significant fraction of the genes differentially expressed in response to diverse stressful stimuli and, once induced, contribute to the regulation of downstream cellular processes, including feedback regulation of key stress response proteins. While many lncRNAs seem to be induced in response to a specific stress, there is significant overlap between lncRNAs induced in response to different stressful stimuli. In addition to stress-induced RNAs, several constitutively expressed lncRNAs also exert a strong regulatory impact on the stress response. Although our understanding of the contribution of lncRNAs to the cellular stress response is still highly rudimentary, the existing data point to the presence of a complex network of lncRNAs, miRNAs, and proteins in regulation of the cellular response to stress.
所有生物通过复杂的信号通路感知并响应细胞内和细胞外环境中的有害变化，这些信号通路会导致基因表达和细胞功能发生变化，以维持体内平衡。长链非编码RNA（lncRNA）是一大类功能各异的RNA，在细胞对压力条件的反应中发挥着重要作用。lncRNA构成了在对各种压力刺激的反应中差异表达的基因的很大一部分，一旦被诱导，它们就会参与下游细胞过程的调控，包括对关键应激反应蛋白的反馈调节。虽然许多lncRNA似乎是在对特定压力的反应中被诱导产生的，但在对不同压力刺激的反应中诱导产生的lncRNA之间存在显著重叠。除了应激诱导的RNA外，一些组成型表达的lncRNA也对应激反应产生强烈的调节作用。尽管我们对lncRNA在细胞应激反应中的作用的理解仍然非常初步，但现有数据表明，在细胞应激反应的调控中存在一个由lncRNA、miRNA和蛋白质组成的复杂网络。
