Khan M A, Braun W E, Kushner I, Grecek D E, Muir W A, Steinberg A G
J Rheumatol Suppl. 1977;3:39-43.
Twenty-eight HLA alleles of the A and B loci were determined in 23 American Blacks and 50 Caucasians with primary ankylosing spondylitis (AS). The prevalence of HLA B27 was significantly increased in American Black patients (48 per cent) vs Black controls (two per cent), but was much less than the 94 per cent found in Caucasian patients (controls eight per cent). The lower prevalence of B27 in American Black patients vs Caucasian patients was significant (p less than 0.001), and indicated that susceptibility to AS is not as closely associated with B27 in Blacks as in Caucasians. No other HLA antigen was significantly associated with AS in either racial group. Among B27 positive individuals, the relative risk of developing AS was significantly lower in American Blacks than in Caucasians. These data indicate that for diagnostic purposes, the absence of B27 is less important in ruling out AS in Blacks than in Caucasians.
对23名患有原发性强直性脊柱炎（AS）的美国黑人患者和50名白人患者进行了A和B位点的28个HLA等位基因检测。美国黑人AS患者中HLA B27的患病率（48%）显著高于黑人对照组（2%），但远低于白人患者中的94%（白人对照组为8%）。美国黑人患者中B27的患病率低于白人患者，差异具有统计学意义（p<0.001），这表明黑人AS易感性与B27的关联不如白人紧密。在两个种族群体中，均无其他HLA抗原与AS显著相关。在B27阳性个体中，美国黑人患AS的相对风险显著低于白人。这些数据表明，就诊断而言，B27阴性在排除黑人AS方面不如在排除白人AS方面重要。
