Kopplin Laura J, Mount George, Suhler Eric B
a Casey Eye Institute, Oregon Health & Science University , Portland , Oregon , USA.
b Portland Veterans Affairs Health Care System , Portland , Oregon , USA.
Ocul Immunol Inflamm. 2016 Aug;24(4):470-5. doi: 10.1080/09273948.2016.1175642. Epub 2016 May 27.
Acute anterior uveitis is generally recognized as the most common form of uveitis. An association with HLA-B27 is seen in approximately half of cases of acute anterior uveitis. The prevalence of HLA-B27 varies widely between ethnic populations, with an approximate 8-10% prevalence in non-Hispanic whites and lower prevalence in Mexican- (4%) and African- (2-4%) Americans. A group of systemic inflammatory diseases, the spondyloarthropathies, similarly demonstrates a strong association with HLA-B27. The strength of association varies, depending on the specific spondyloarthropathy, with the strongest association found in patients with ankylosing spondylitis. The majority of patients with HLA-B27 associated uveitis will have an underlying spondyloarthropathy. Suspicion for HLA-B27 associated uveitis should prompt a careful clinical history to assess for features of a spondyloarthropathy as the characteristics of any associated uveitis may vary.
急性前葡萄膜炎通常被认为是葡萄膜炎最常见的形式。在大约一半的急性前葡萄膜炎病例中可见与HLA - B27相关。HLA - B27的患病率在不同种族人群中差异很大，非西班牙裔白人中的患病率约为8 - 10%，而在墨西哥裔美国人（4%）和非裔美国人（2 - 4%）中患病率较低。一组系统性炎症性疾病，即脊柱关节病，同样显示出与HLA - B27有很强的相关性。相关性的强度有所不同，取决于具体的脊柱关节病，在强直性脊柱炎患者中发现的相关性最强。大多数HLA - B27相关葡萄膜炎患者会有潜在的脊柱关节病。怀疑HLA - B27相关葡萄膜炎时应仔细询问临床病史，以评估是否有脊柱关节病的特征，因为任何相关葡萄膜炎的特征可能会有所不同。
