双酚A及其类似物的神经学效应。
Neurological Effects of Bisphenol A and its Analogues.
作者信息
Inadera Hidekuni
机构信息
Department of Public Health, Faculty of Medicine, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan.
出版信息
Int J Med Sci. 2015 Oct 30;12(12):926-36. doi: 10.7150/ijms.13267. eCollection 2015.
Abstract
The endocrine disrupting chemical bisphenol A (BPA) is widely used in the production of polycarbonate plastics and epoxy resins. The use of BPA-containing products in daily life makes exposure ubiquitous, and the potential human health risks of this chemical are a major public health concern. Although numerous in vitro and in vivo studies have been published on the effects of BPA on biological systems, there is controversy as to whether ordinary levels of exposure can have adverse effects in humans. However, the increasing incidence of developmental disorders is of concern, and accumulating evidence indicates that BPA has detrimental effects on neurological development. Other bisphenol analogues, used as substitutes for BPA, are also suspected of having a broad range of biological actions. The objective of this review is to summarize our current understanding of the neurobiological effects of BPA and its analogues, and to discuss preventive strategies from a public health perspective.
摘要
内分泌干扰化学物质双酚A（BPA）广泛用于聚碳酸酯塑料和环氧树脂的生产。日常生活中使用含BPA的产品使得接触无处不在，这种化学物质对人类健康的潜在风险是一个重大的公共卫生问题。尽管已经发表了大量关于BPA对生物系统影响的体外和体内研究，但对于普通接触水平是否会对人类产生不利影响仍存在争议。然而，发育障碍发病率的上升令人担忧，越来越多的证据表明BPA对神经发育有有害影响。用作BPA替代品的其他双酚类似物也被怀疑具有广泛的生物学作用。本综述的目的是总结我们目前对BPA及其类似物神经生物学效应的理解，并从公共卫生角度讨论预防策略。
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